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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2020

01-03-2020 | Mastectomy | ASO Author Reflections

ASO Author Reflections: Neoadjuvant Chemotherapy for Breast Cancer May Not Alter Increasing Trends for CPM Utilization

Authors: Nicole Christian, MD, Mary L. Gemignani, MD, MPH

Published in: Annals of Surgical Oncology | Issue 3/2020

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Excerpt

Currently, the use of neoadjuvant chemotherapy (NAC) for breast cancer increases eligibility for breast-conserving surgery (BCS) and decreases need for axillary node dissection. The survival of women undergoing BCS after NAC is equivalent to those undergoing mastectomy.1,2 Clinical trials have reported improved pathologic complete response rates with modern chemotherapy regimens without a corresponding increase in BCS rates.2,3 …
Literature
1.
Golshan M, Cirrincione CT, Sikov WM, et al. Impact of neoadjuvant therapy on eligibility for and frequency of breast conservation in stage II–III HER2-positive breast cancer: surgical results of CALGB 40601 (Alliance). Breast Cancer Res Treat. 2016;160(2):297–304.CrossRef
2.
Kantor O, Ajmani G, Wang CH, Datta A, Yao K. The shifting paradigm for breast cancer surgery in patients undergoing neoadjuvant chemotherapy. Ann Surg Oncol. 2018;25(1):164–72.CrossRef
3.
Pollom EL, Qian Y, Chin AL, et al. Rising rates of bilateral mastectomy with reconstruction following neoadjuvant chemotherapy. Int J Cancer. 2018;143(12):3262–72.CrossRef
4.
Wapnir IL, Kurian AW, Lichtensztajn DY, Clarke CA, Gomez SL. Rising bilateral mastectomy rates among neoadjuvant chemotherapy recipients in california from 1998 to 2012. Ann Surg. 2017;266(2):353–60.CrossRef
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Wong SM, Freedman RA, Sagara Y, Aydogan F, Barry WT, Golshan M. Growing use of contralateral prophylactic mastectomy despite no improvement in long-term survival for invasive breast cancer. Ann Surg. 2017;265(3):581–9.CrossRef
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Metadata
Title
ASO Author Reflections: Neoadjuvant Chemotherapy for Breast Cancer May Not Alter Increasing Trends for CPM Utilization
Authors
Nicole Christian, MD
Mary L. Gemignani, MD, MPH
Publication date
01-03-2020
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 3/2020
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-08082-4

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