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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2019

Open Access 01-12-2019 | Breast Cancer | ASO Author Reflections

ASO Author Reflections: The Changing Role of Gene Expression Profiling in ER+/HER2− Breast Cancer

Authors: Julia E. C. van Steenhoven, MD, T. van Dalen, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2019

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Excerpt

International guidelines increasingly question the benefit of adjuvant chemotherapy in selections of estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer patients.1 At the same time, and in the same selection of patients, gene expression profiles (GEPs), such as the 70-gene signature (70-GS), are used as a means to better guide chemotherapy decisions. Previous studies demonstrated that use of the 70-GS was associated with a significant reduction in chemotherapy administration in patients with ER+/HER2− disease of low or intermediate malignancy grade without overt lymph node metastasis (≤ Nmi).2 In the present study, we assessed recent trends in the administration of adjuvant chemotherapy in patients eligible for GEPs and evaluated the role of the 70-GS on chemotherapy administration in lymph node-negative (N0) and lymph node-positive (N+) breast cancer patients. …
Literature
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Coates AS, Winter EP, Goldhirsch A, et al. Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015. Ann Oncol. 2015;26(8):1533–46.CrossRef
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Kuijer A, van Bommel ACM, Drukker CA, et al. Using a gene expression signature when controversy exists regarding the indication for adjuvant systemic treatment reduces the proportion of patients receiving adjuvant chemotherapy: a nationwide study. Genet Med. 2016;18(7):769–75.CrossRef
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Kwaliteitsinstituut voor de gezondheidszorg CBO VvIK. Landelijke Richtlijn mammacarcinoom; 2012.
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Steenhoven JEC, Kuijer A, Schreuder K, et al. The changing role of gene-expression profiling in the era of de-escalating adjuvant chemotherapy in early-stage breast cancer. Ann Surg Oncol. 2019;26:3495–501.CrossRef
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Cardoso F, van’t Veer LJ, Bogaerts J, Slaets L, et al. 70 gene signature as an aid to treatment decisions in early-stage breast cancer. N Engl J Med. 2016;375:717–29.CrossRef
Metadata
Title
ASO Author Reflections: The Changing Role of Gene Expression Profiling in ER+/HER2− Breast Cancer
Authors
Julia E. C. van Steenhoven, MD
T. van Dalen, MD, PhD
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07955-y

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