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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2019

Open Access 01-12-2019 | Mastectomy | ASO Author Reflections

ASO Author Reflections: SPIO, a New Sentinel Node Tracer with Interesting Future Clinical Applications

Authors: Fredrik Wärnberg, MD, Andreas Karakatsanis, PhD, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2019

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Excerpt

Superparamagnetic iron oxide nanoparticles (SPIO) is a new tracer for sentinel node (SN) detection with comparable results to dual technique, Technetium99 ± blue dye.1 SPIO has not been associated with allergic reactions, and nuclear medicine facilities are not required. Concerns have however been raised regarding artifacts on magnetic resonance imaging (MRI) and brownish skin staining. …
Literature
1.
Karakatsanis A, Christiansen PM, Fischer L, Hedin C, Pistioli L, Sund M, et al. The Nordic SentiMag trial: a comparison of super paramagnetic iron oxide (SPIO) nanoparticles versus Tc(99) and patent blue in the detection of sentinel node (SN) in patients with breast cancer and a meta-analysis of earlier studies. Breast Cancer Res Treat 2016;157(2):281–94.CrossRef
2.
Karakatsanis A, Olofsson H, Stålberg P, et al. Simplifying logistics and avoiding the unnecessary in patients with breast cancer undergoing sentinel node biopsy. A prospective feasibility trial of the preoperative injection of super paramagnetic iron oxide nanoparticles. Scand J Surg 2018;107(2):130–37.CrossRef
3.
Wärnberg F, Stigberg E, Obondo C, Olofsson H, Abdsaleh S, Wärnberg M, Karakatsanis A. Long-term outcome after retroareolar versus peritumoral injection of superparamagnetic iron oxide nanoparticles (SPIO) for sentinel lymph node detection in breast cancer surgery. Ann Surg Oncol 2019;26:1247–53.CrossRef
4.
Karakatsanis A, Hersi AF, Pistiolis L, Olofsson Bagge R, Lykoudis PM, Eriksson S, Wärnberg F, SentiNot Trialists Group. Effect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study). Br J Surg 2019;106(6):720–28.CrossRef
5.
Hersi AF, Eriksson S, Ramos J, Abdsaleh S, Wärnberg F, Karakatsanis A. A combined, totally magnetic technique with a magnetic marker for non-palpable tumour localization and superparamagnetic iron oxide nanoparticles for sentinel lymph node detection in breast cancer surgery. Eur J Surg Oncol 2018. https://​doi.​org/​10.​1016/​j.​ejso.​2018.​10.​064. [Epub ahead of print].CrossRefPubMed
Metadata
Title
ASO Author Reflections: SPIO, a New Sentinel Node Tracer with Interesting Future Clinical Applications
Authors
Fredrik Wärnberg, MD
Andreas Karakatsanis, PhD, MD
Publication date
01-12-2019
Publisher
Springer International Publishing
Keyword
Mastectomy
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07520-7

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