Published in:
01-12-2019 | Colorectal Cancer | ASO Author Reflections
ASO Author Reflections: Analysis of PD-L1 Expression and Immunoscore in Colorectal Cancer
Author:
Takato Yomoda, MD
Published in:
Annals of Surgical Oncology
|
Special Issue 3/2019
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Excerpt
Host immune response, including tumor-infiltrating lymphocytes (TILs), plays an important role in colorectal cancer (CRC) and other malignant diseases.
1 Interest in the use of immune checkpoint inhibitors (ICIs) as part of a new therapeutic strategy has increased. Immunoscore (IS) defined by the evaluation of TILs is reported to be a significantly better prognostic indicator in CRC.
2,
3 There is a possibility that IS becomes one key element to decide the use of ICIs. On the other hand, whether expression of PD-1 or PD-L1 is predictive of ICIs effectiveness is controversial. PD-L1 expression is observed not only in tumor cells (TCs) but also in tumor-infiltrating mononuclear cells (TIMCs). The expression of PD-L1 on TCs correlates with poor prognosis in various malignancies; however, few studies have investigated the association between PD-L1 expression in TIMCs and the prognosis of CRC patients and the significance of its expression is questioned. …
