Published in:
01-12-2018 | ASO Author Reflections
ASO Author Reflections: PD-1 Expression in Bacillus Calmette–Guérin-Relapsing Bladder Cancer
Authors:
Keishiro Fukumoto, MD, PhD, Eiji Kikuchi, MD, PhD
Published in:
Annals of Surgical Oncology
|
Special Issue 3/2018
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Excerpt
Programmed cell death (PD)-1 is attracting attention as an important pathway for carcinomas to escape the host immune system.
1 Several studies including urothelial carcinoma have revealed that PD-1 and its ligand, PD-L1 are correlated with poor outcomes.
2 However, although Bacillus Calmette–Guérin (BCG) is an important immune therapy for bladder cancers, there is little information about the impact of BCG on PD-1 expression. We focused on bladder cancers with BCG relapsing,
3 defined as recurrence after achieving disease-free status by initial BCG instillations for 6 months,
4 and evaluated the change of PD-1 expression between before and after BCG therapy and its clinical significance. …
