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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2018

01-12-2018 | ASO Author Reflections

ASO Author Reflections: Improving Identification of Intraductal Papillary Mucinous Neoplasm Patients at Risk—Current Status and the Role of IPMN Molecular Biomarkers

Author: Ajay V. Maker, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2018

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Excerpt

Within our generation, we have witnessed an evolution of surgery for cystic lesions of the pancreas, particularly intraductal papillary mucinous neoplasms (IPMNs). Recommendations for surgical resection have progressed from resection of all lesions to resection of only selected IPMNs based on an estimation of malignant risk. Since the characterization and terminology of what constitutes an IPMN has evolved over the last 22 years since the WHO definition, the reported incidence of malignancy in surgically treated patients has fluctuated based on the time period of reporting. The purpose of the current study was to create a snapshot of the rate of malignancy in resected IPMNs that is reflective of the current surgical era post-establishment of recent international consensus guidelines. …
Literature
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Lekkerkerker SJ, Besselink MG, Busch OR, Verheij J, Engelbrecht MR, Rauws EA, et al. Comparing 3 guidelines on the management of surgically removed pancreatic cysts with regard to pathological outcome. Gastrointest Endosc. 2017;85(5):1025–31.CrossRefPubMed
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Khoury RE, Kabir C, Maker VK, Banulescu M, Wasserman M, Maker AV. What is the incidence of malignancy in resected intraductal papillary mucinous neoplasms? An analysis of over 100 US institutions in a single year. Ann Surg Oncol. 2018;25(6):1746–51.CrossRefPubMed
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Tulla KA, Maker AV. Can we better predict the biologic behavior of incidental IPMN? A comprehensive analysis of molecular diagnostics and biomarkers in intraductal papillary mucinous neoplasms of the pancreas. Langenbecks Arch Surg. 2018;403(2):151–94.PubMed
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Maker AV, Carrara S, Jamieson NB, Pelaez-Luna M, Lennon AM, Dal Molin M, et al. Cyst fluid biomarkers for intraductal papillary mucinous neoplasms of the pancreas: a critical review from the international expert meeting on pancreatic branch-duct-intraductal papillary mucinous neoplasms. J Am Coll Surg. 2015;220(2):243–53.CrossRefPubMed
Metadata
Title
ASO Author Reflections: Improving Identification of Intraductal Papillary Mucinous Neoplasm Patients at Risk—Current Status and the Role of IPMN Molecular Biomarkers
Author
Ajay V. Maker, MD
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6901-z

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