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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2018

01-12-2018 | ASO Author Reflections

ASO Author Reflections: The Whole Transcriptome Landscape of Circulating Tumor Cells in Nonmetastatic Breast Cancer

Authors: Julie E. Lang, MD, Kirstyn E. Brownson, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2018

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Excerpt

Circulating tumor cells (CTCs) have been demonstrated to be prognostic in all stages of breast cancer.1,2 However, few clinicians have incorporated them into practice, because CTCs did not predict which specific therapy would be effective in treating patients.3 The Fisher paradigm contends that operable breast cancer is a systemic disease at its inception and that in addition to proper surgical management, optimal systemic therapy is critical to disease survival outcomes.4 Previous generations of CTC assays were limited by technical factors relating to the rarity of CTCs, cellular marker expression, lack of blood preservation tubes compatible with downstream assays, and the high cost of next-generation sequencing.5 This study evaluated the hypothesis that it is feasible to isolate and profile CTCs from stage II–III breast cancer patients before receipt of surgery or systemic therapy.6 We evaluated known and novel biomarkers using RNA sequencing to characterize the whole transcriptome of CTCs, because not all DNA mutations are expressed. …
Literature
1.
Lucci A, Hall CS, Lodhi AK, et al. Circulating tumour cells in non-metastatic breast cancer: a prospective study. Lancet Oncol. 2012;13(7):688–95.CrossRefPubMed
2.
Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 2004;351(8):781–91.CrossRefPubMed
3.
Smerage JB, Barlow WE, Hortobagyi GN, et al. Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500. J Clin Oncol. 2014;32(31):3483–9.CrossRefPubMedPubMedCentral
4.
Fisher B. The evolution of paradigms for the management of breast cancer: a personal perspective. Cancer Res. 1992;52(9):2371–83.PubMed
5.
Forte VA, Barrak DK, Elhodaky M, Tung L, Snow A, Lang JE. The potential for liquid biopsies in the precision medical treatment of breast cancer. Cancer Biol Med. 2016;13(1):19–40.CrossRefPubMedPubMedCentral
6.
Lang JE, Ring A, Porras T, et al. RNA-Seq of circulating tumor cells in stage II–III breast cancer. Ann Surg Oncol. 2018;25:2261–70.CrossRefPubMed
Metadata
Title
ASO Author Reflections: The Whole Transcriptome Landscape of Circulating Tumor Cells in Nonmetastatic Breast Cancer
Authors
Julie E. Lang, MD
Kirstyn E. Brownson, MD
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6888-5

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