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01-12-2018 | ASO Author Reflections

ASO Author Reflections: Hepatic Artery Infusion (HAI) Chemotherapy is Associated with Improved Survival Compared with Radioembolization (Y90) in Patients with Isolated Unresectable Colorectal Liver Metastases

Authors: Mashaal Dhir, MD, Amer H. Zureikat, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2018

Excerpt

Modern chemotherapy forms the backbone of treatment for isolated unresectable colorectal liver metastases (IU-CRLM). Although response rates can exceed 60% in the first-line systemic setting, second-line chemotherapy regimens are associated with poor response rates (20–30%) and median survival of 1 year. Although hepatic artery infusion (HAI) therapy and yttrium-90 radioembolization (Y90) are used in patients with IU-CRLM,1,2 there are no data on the comparative effectiveness of either regional modality when used in conjunction with modern chemotherapy. Additionally, cost analysis of either regional modality has not been performed. In this study, we compared the overall survival (OS) of second-line HAI versus Y90 for IU-CRCLM patients treated with modern chemotherapy and performed a cost analysis of both regional modalities. …

Hickey R, Lewandowski RJ, Prudhomme T, et al. 90Y radioembolization of colorectal hepatic metastases using glass microspheres: safety and survival outcomes from a 531-patient multicenter study. J Nucl Med. 2016;57(5):665–71.CrossRefPubMed

Dhir M, Jones HL, Shuai Y, et al. Hepatic arterial infusion in combination with modern systemic chemotherapy is associated with improved survival compared with modern systemic chemotherapy alone in patients with isolated unresectable colorectal liver metastases: a case–control study. Ann Surg Oncol. 2017;24(1):150–8.CrossRefPubMed

Dhir M, Zenati MS, Jones HL, et al. Effectiveness of hepatic artery infusion (HAI) versus selective internal radiation therapy (Y90) for pretreated isolated unresectable colorectal liver metastases (IU-CRCLM). Ann Surg Oncol. 2018;25(2):550–7.CrossRefPubMed

Title: ASO Author Reflections: Hepatic Artery Infusion (HAI) Chemotherapy is Associated with Improved Survival Compared with Radioembolization (Y90) in Patients with Isolated Unresectable Colorectal Liver Metastases
Authors: Mashaal Dhir, MD
Amer H. Zureikat, MD
Publication date: 01-12-2018
Publisher: Springer International Publishing
Published in: Annals of Surgical Oncology / Issue Special Issue 3/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-018-6834-6

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ASO Author Reflections: Hepatic Artery Infusion (HAI) Chemotherapy is Associated with Improved Survival Compared with Radioembolization (Y90) in Patients with Isolated Unresectable Colorectal Liver Metastases

Excerpt

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