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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2018

01-12-2018 | ASO Author Reflections

ASO Author Reflections: Esophagectomy Versus Nonsurgical Treatment for Resectable Esophageal Cancer

Author: Yu Ohkura, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2018

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Excerpt

Currently, many patients achieve clinical complete response (cCR) to neoadjuvant therapies [neoadjuvant chemotherapy (NACT) and neoadjuvant chemoradiotherapy (NACRT)]. In patients with pathological complete response (pCR), conservative treatment may be an option so as to avoid invasive surgery. However, there is no consensus on the best treatment for patients with resectable esophageal cancer showing cCR to neoadjuvant therapy,1,2 and, to our knowledge, no comprehensive comparative study between surgery and conservative treatment of this condition (including both NACT and NACRT) has been performed. The aim of our study3 was to clarify the prognostic impact of surgery or nonsurgical treatment for patients with esophageal cancer showing cCR to neoadjuvant therapy. …
Literature
1.
Piessen G, Messager M, Mirabel X, et al. Is there a role for surgery for patients with a complete clinical response after chemoradiation for esophageal cancer? An intention-to-treat case-control study. Ann Surg. 2013;258:793–9.CrossRefPubMed
2.
Bedenne L, Michel P, Bouché O, et al. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol. 2007;25:1160–8.CrossRefPubMed
3.
Ohkura Y, Shindoh J, Ueno M, Iizuka T, Udagawa H. Comparison of outcome of esophagectomy versus nonsurgical treatment for resectable esophageal cancer with clinical complete response to neoadjuvant therapy. Ann Surg Oncol. 2018:25:2428–33.CrossRefPubMed
4.
Shi-Liang L, Mian X, Hong Y, et al. Is there a correlation between clinical complete response and pathological complete response after neoadjuvant chemoradiotherapy for esophageal squamous cell cancer? Ann Surg Oncol. 2016;23:273–81.CrossRef
Metadata
Title
ASO Author Reflections: Esophagectomy Versus Nonsurgical Treatment for Resectable Esophageal Cancer
Author
Yu Ohkura, MD
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6781-2

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