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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 6/2018

01-06-2018 | Gastrointestinal Oncology

Long-Term Outcomes of Gastric Cancer Patients with Preoperative Sarcopenia

Authors: Taiichi Kawamura, Rie Makuuchi, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Hiroshi Yasui, Takashi Aoyama, Toshimi Inano, Masanori Terashima

Published in: Annals of Surgical Oncology | Issue 6/2018

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Abstract

Background

There are few reports of long-term outcomes of gastric cancer patients with sarcopenia. The purpose of this study was to assess the impact of sarcopenia on long-term outcomes in gastric cancer patients who underwent curative resection.

Methods

A total of 951 patients aged 65 years or older who underwent R0 resection for gastric cancer were investigated. Sarcopenia was defined as a decreased arm muscle area < 38.05 cm2 in men and < 27.87 cm2 in women combined with a decline in grip strength to < 26 kgf in men and < 18 kgf in women.

Results

Of 951 patients, 111 (11.7%) were diagnosed with sarcopenia. Reduced surgery was performed significantly more frequently in patients with sarcopenia (p = 0.006). The incidence of eligible patients who received adjuvant chemotherapy was significantly lower in patients with sarcopenia than in those without sarcopenia (p = 0.030). Mortality due to gastric cancer and aging-associated multiple organ failure rates without obvious diseases were higher in patients with sarcopenia (p = 0.036 and p < 0.001, respectively). Overall survival (OS) and cause-specific survival (CSS) were significantly worse in patients with sarcopenia (p < 0.001 and p = 0.005, respectively). Multivariate analysis for OS and CSS revealed that sarcopenia was an independent prognostic factor in gastric cancer patients (p < 0.001 and p = 0.043, respectively).

Conclusions

Sarcopenia is related to poor survival in gastric cancer patients and appears to be a significant negative prognostic factor in patients with gastric cancer who underwent curative resection.
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Metadata
Title
Long-Term Outcomes of Gastric Cancer Patients with Preoperative Sarcopenia
Authors
Taiichi Kawamura
Rie Makuuchi
Masanori Tokunaga
Yutaka Tanizawa
Etsuro Bando
Hiroshi Yasui
Takashi Aoyama
Toshimi Inano
Masanori Terashima
Publication date
01-06-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 6/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6452-3

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