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01-08-2017 | Colorectal Cancer

Is Fecal Diversion Needed in Pelvic Anastomoses During Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?

Authors: Matthew D. Whealon, MD, John V. Gahagan, MD, Sarath Sujatha-Bhaskar, MD, Michael P. O’Leary, MD, Matthew Selleck, DO, Sinziana Dumitra, MD, Byrne Lee, MD, Maheswari Senthil, MD, Alessio Pigazzi, MD, PhD

Published in: Annals of Surgical Oncology | Issue 8/2017

Abstract

Background

The role of fecal diversion with pelvic anastomosis during cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is not well defined.

Methods

A retrospective review of patients who underwent CRS and HIPEC between 2009 and 2016 was performed to identify those with a pelvic anastomosis (colorectal, ileorectal, or coloanal anastomosis).

Results

The study identified 73 patients who underwent CRS and HIPEC at three different institutions between July 2009 and June of 2016. Of these patients, 32 (44%) underwent a primary anastomosis with a diverting ileostomy, whereas 41 (56%) underwent a primary anastomosis without fecal diversion. The anastomotic leak rate for the no-diversion group was 22% compared with 0% for the group with a diverting ileostomy (p < 0.01). The 90-day mortality rate for the no-diversion group was 7.1%. The hospital stay was 14.1 ± 8.0 days in the diversion group compared with 17.9 ± 12.5 days in the no-diversion group (p = 0.12). Of those patients with a diverting ileostomy, 68% (n = 22) had their bowel continuity restored, 18% of which required a laparotomy for reversal. Postoperative complications occurred for 50% of those who required a laparotomy and for 44% of those who did not require a laparotomy (p = 0.84).

Conclusion

Diverting ileostomies in patients with a pelvic anastomosis undergoing CRS and HIPEC are associated with a significantly reduced anastomotic leak rate. Reversal of the diverting ileostomy in this patient population required a laparotomy in 18% of the cases and had an associated morbidity rate of 50%.

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Title: Is Fecal Diversion Needed in Pelvic Anastomoses During Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?
Authors: Matthew D. Whealon, MD
John V. Gahagan, MD
Sarath Sujatha-Bhaskar, MD
Michael P. O’Leary, MD
Matthew Selleck, DO
Sinziana Dumitra, MD
Byrne Lee, MD
Maheswari Senthil, MD
Alessio Pigazzi, MD, PhD
Publication date: 01-08-2017
Publisher: Springer International Publishing
Published in: Annals of Surgical Oncology / Issue 8/2017
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-017-5853-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Is Fecal Diversion Needed in Pelvic Anastomoses During Hyperthermic Intraperitoneal Chemotherapy (HIPEC)?

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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