Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 12/2016

01-11-2016 | Thoracic Oncology

Gastroesophageal Junction Tumors

Author: Nabil Rizk, MD

Published in: Annals of Surgical Oncology | Issue 12/2016

Login to get access

Excerpt

The persistent debate regarding the management of gastroesophageal (GE) junction tumors is somewhat of a self-inflicted wound, in that its roots can be attributed to a single group that popularized both the nomenclature and the treatment strategy,1 , 2 but for which no large retrospective study has since adequately investigated, for which the biologic and anatomic bases for the distinction are thin,3 – 5 and for which prospective randomized trials that included theses GE junction tumors treated them variably as gastric cancers 6 , 7 or esophageal cancers.8 Consequently, despite firm convictions on how to manage these tumors, we in fact currently have very little useful information from which to base the clinical treatment of these tumors. The level of evidence used to support various recommendations would be considered primarily level III using the US Preventive Task Force criteria, and the practice recommendations would be grade C as a consequence. …
Literature
1.
Siewert JR, Stein HJ. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg. 1998;85:1457–9.CrossRefPubMed
2.
Siewert JR, Feith M, Werner M. Adenocarcinoma of the esophagogastric junction: results of surgical therapy based on anatomical/topographic classification in 1,002 consecutive patients. Ann Surg. 2000;232:353–61.CrossRef
3.
Curtis NJ, Noble F, Bailey IS, et al. The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction. J Surg Oncol. 2014;109:202–7.CrossRefPubMed
4.
Siewert JR, Feith M. Adenocarcinoma of the esophagogastric junction: competition between Barrett and gastric cancer. J Am Coll Surg. 2007;205:s49–53.CrossRefPubMed
5.
Rusch VW. Are cancers of the esophagus, gastroesophageal junction, and cardia one disease, two, or several? Semin Oncol. 2004;31:444–9.CrossRefPubMed
6.
Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355:11–20.CrossRefPubMed
7.
Macdonald JS, Stephen S, Malley RS, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345:725–30.CrossRefPubMed
8.
van Hagen P, Hulshof MC, van Lanschot JJ, et al. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012;366:2074–84.CrossRefPubMed
9.
Burkhard H, von Rhaden A, Feith M, et al. Carcinoma of the cardia: classification as esophageal or gastric cancer? Int J Colorectal Dis. 2005;20:89–93.CrossRef
10.
Rice TW, Blackstone EH, Rusch WV. 7th Edition of the AJCC cancer staging manual: esophagus and esophagogastric junction. Ann Surg Oncol. 2010;17:1721–4.CrossRefPubMed
11.
Buas MF, Vaughn TL. Epidemiology and risk factors for gastroesophageal junction tumors: understanding the rising incidence of this disease. Semin Radiat Oncol. 2013;23:3–9.CrossRefPubMedPubMedCentral
12.
13.
Power DG, Shatner MA, Gerdes H, et al. Endoscopic ultrasound can improve the selection for laparoscopy in patients with localized gastric cancer. J Am Coll Surg. 2009;208(2):173–8.CrossRefPubMed
14.
Bentrem DJ, Wilton A, Mazumdar M, et al. The value of peritoneal cytology as a preoperative predictor in patients with gastric carcinoma undergoing a curative resection. Ann Surg Oncol. 2005;12(5):347–53.CrossRefPubMed
15.
Mariette C, Piessen G, Lamblin A, et al. Impact of preoperative radiochemotherapy on postoperative course and survival in patients with locally advanced squamous cell oesophageal carcinoma. Br J Surg. 2006;93(9):1077–83.CrossRefPubMed
16.
Dexter SP, Sue-Ling H, McMahon MJ, et al. Circumferential resection margin involvement: an independent predictor of survival following surgery for oesophageal cancer. Gut. 2001;48(5):667–70.CrossRefPubMedPubMedCentral
17.
Sagar PM, Johnston D, McMahon MJ, et al. Significance of circumferential resection margin involvement after oesophagectomy for cancer. Br J Surg. 1993;80(11):1386–8.CrossRefPubMed
18.
Hosokawa Y, Kinoshita T, Konishi M, et al. Recurrence patterns of esophagogastric junction adenocarcinoma according to Siewert’s classification after radical resection. Anticancer Res. 2014;34:4391–8.PubMed
19.
Zhang WH, Chen XZ, Liu K, et al. Comparison of the clinicopathologic characteristics and the survival outcomes between the Siewert II/III adenocarcinomas. Med Oncol. 2014;31:116–24.CrossRefPubMed
20.
Meier I, Merkel S, Papadopolous T, et al. Adenocarcinoma of the esophagogastric junction: the pattern of metastatic lymph node dissemination as a rationale for elective lymphatic volume definition. Int J Radiat Oncol Biol Phys. 2008;70:1408–17.CrossRefPubMed
21.
Fujitani K, Miyashiro I, Mikata S, et al. Pattern of abdominal nodal spread and optimal abdominal lymphadenectomy for advanced Siewert Type II adenocarcinoma of the cardia: results of a multicenter study. Gastric Cancer. 2013;16:301–8.CrossRefPubMed
22.
Hasegawa S, Yoshikawa T, Rini Y, et al. Priority of lymph node dissection for Siewert II/III adenocarcinoma of the esophagogastric junction. Ann Surg Oncol. 2013;20:4252–9.CrossRefPubMed
23.
Hulscher J, van Sandick J, DeBoer A, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med. 2002;347:1662–9.CrossRefPubMed
24.
Biere Y, Henegouwen M, Maas KW, et al. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomized controlled trial. Lancet. 2012;379:1887–92.CrossRefPubMed
25.
Rizk NP, Ishwaran H, Rice TW, et al. Optimum lymphadenectomy for esophageal cancer. Ann Surg. 2010;251(1):46–50.CrossRefPubMed
26.
Migliore M, Rassl D, Criscione A. Longitudinal and circumferential resection margin in adenocarcinoma of the distal esophagus and cardia. Future Oncol. 2014;10:891–901.CrossRefPubMed
27.
Sasaki M, Sano T, Yamamoto S, et al. Left thoracoabdominal versus abdominal-transhiatal approach for gastric cancer of the cardia or subcardia: a randomized controlled trial. Lancet Oncol. 2006;7:644–51.CrossRef
Metadata
Title
Gastroesophageal Junction Tumors
Author
Nabil Rizk, MD
Publication date
01-11-2016
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 12/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-016-5427-5

Other articles of this Issue 12/2016

Annals of Surgical Oncology 12/2016 Go to the issue

Gynecologic Oncology

The Incidence of Unexpected Uterine Malignancy in Women Undergoing Hysterectomy for a Benign Condition: A National Population-Based Study

Breast Oncology

Locoregional Recurrence Risk for Postmastectomy Breast Cancer Patients With T1–2 and One to Three Positive Lymph Nodes Receiving Modern Systemic Treatment Without Radiotherapy

Melanomas

Invasive Scalp Melanoma: Role for Enhanced Detection Through Professional Training

Gastrointestinal Oncology

The Multidisciplinary Approach to GI Cancer Results in Change of Diagnosis and Management of Patients. Multidisciplinary Care Impacts Diagnosis and Management of Patients

Breast Oncology

Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ

Colorectal Cancer

Sarcopenia is Associated with Chemotherapy Toxicity in Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Colorectal Cancer