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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 12/2016

01-11-2016 | Melanomas

Pediatric and Adolescent Melanoma: A National Cancer Data Base Update

Authors: Patrick D. Lorimer, MD, Richard L. White, MD, Kendall Walsh, BA, Yimei Han, MS, Russell C. Kirks, MD, James Symanowski, PhD, Meghan R. Forster, MD, Terry Sarantou, MD, Jonathan C. Salo, MD, Joshua S. Hill, MD

Published in: Annals of Surgical Oncology | Issue 12/2016

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Abstract

Background

Studies suggest that the biology of pediatric and adolescent melanoma differs from that of adult disease. We report the largest series to date examining the natural history of pediatric and adolescent melanoma. We aim to elucidate the natural history of pediatric and adolescent melanoma and to examine the appropriateness of diagnostic and therapeutic modalities developed for adults and that are currently being used in children.

Methods

A retrospective cohort study was conducted of patients with an index diagnosis of cutaneous non-metastatic melanoma from 1998 to 2011 using the National Cancer Data Base (NCDB; n = 420,416). Three age-based cohorts were analyzed: 1–10 years (pediatric), 11–20 years (adolescent), and ≥21 years (adult). Multivariate analyses were used to identify factors associated with overall survival (OS).

Results

Pediatric melanoma patients have longer OS than their adolescent (hazard ratio [HR] 0.50, 95 % CI 0.25–0.98) and adult counterparts (HR 0.11, 95 % CI 0.06–0.21). Adolescents have longer OS than adults. No difference was found in OS in pediatric patients who are node-positive versus node-negative. In pediatric patients, sentinel lymph node biopsy and completion lymph node dissection are not associated with increased OS. In adolescents, nodal positivity is a significant negative prognostic indicator (HR 4.82, 95 % CI 3.38–6.87).

Conclusions

Age-based differences in melanoma outcomes warrant different considerations for diagnostic and therapeutic approaches in each group in order to maximize quality of life while minimizing complications and costs. Prospective, multicenter studies should evaluate the role of diagnostic procedures for pediatric patients.
Literature
1.
Slade AD, Austin MT. Childhood melanoma: an increasingly important health problem in the USA. Curr Opin Pediatr. 2014;26(3):356-361.CrossRefPubMed
2.
Strouse JJ, Fears TR, Tucker MA, Wayne AS. Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database. J Clin Oncol. 2005;23(21):4735-4741.CrossRefPubMed
3.
Austin MT, Xing Y, Hayes-Jordan AA, Lally KP, Cormier JN. Melanoma incidence rises for children and adolescents: an epidemiologic review of pediatric melanoma in the United States. J Pediatr Surg. 2013;48(11):2207-2213.CrossRefPubMed
4.
5.
Lange JR, Palis BE, Chang DC, Soong SJ, Balch CM. Melanoma in children and teenagers: an analysis of patients from the National Cancer Data Base. J Clin Oncol. 2007;25(11):1363-1368.CrossRefPubMed
6.
Wong JR, Harris JK, Rodriguez-Galindo C, Johnson KJ. Incidence of childhood and adolescent melanoma in the United States: 1973-2009. Pediatrics. 2013;131(5):846-854.CrossRefPubMedPubMedCentral
7.
Campbell LB, Kreicher KL, Gittleman HR, Strodtbeck K, Barnholtz-Sloan J, Bordeaux JS. Melanoma incidence in children and adolescents: decreasing trends in the United States. J Pediatr. 2015;166(6):1505-1513.CrossRefPubMed
8.
Cordoro KM, Gupta D, Frieden IJ, McCalmont T, Kashani-Sabet M. Pediatric melanoma: results of a large cohort study and proposal for modified ABCD detection criteria for children. J Am Acad Dermatol. 2013;68(6):913-925.CrossRefPubMed
9.
Aldrink JH, Selim MA, Diesen DL, et al. Pediatric melanoma: a single-institution experience of 150 patients. J Pediatr Surg. 2009;44(8):1514-1521.CrossRefPubMed
10.
Roaten JB, Partrick DA, Pearlman N, Gonzalez RJ, Gonzalez R, McCarter MD. Sentinel lymph node biopsy for melanoma and other melanocytic tumors in adolescents. J Pediatr Surg. 2005;40(1):232-235.CrossRefPubMed
11.
Saenz NC, Saenz-Badillos J, Busam K, LaQuaglia MP, Corbally M, Brady MS. Childhood melanoma survival. Cancer. 1999;85(3):750-754.CrossRefPubMed
12.
Shah NC, Gerstle JT, Stuart M, Winter C, Pappo A. Use of sentinel lymph node biopsy and high-dose interferon in pediatric patients with high-risk melanoma: the Hospital for Sick Children experience. J Pediatr Hematol Oncol. 2006;28(8):496-500.CrossRefPubMed
13.
Livestro DP, Kaine EM, Michaelson JS, et al. Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis. Cancer. 2007;110(3):614-624.CrossRefPubMed
14.
Howman-Giles R, Shaw HM, Scolyer RA, et al. Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients. Ann Surg Oncol. 2010;17(1):138-143.CrossRefPubMed
15.
Paradela S, Fonseca E, Pita-Fernandez S, et al. Prognostic factors for melanoma in children and adolescents: a clinicopathologic, single-center study of 137 patients. Cancer. 2010;116(18):4334-4344.CrossRefPubMed
16.
Mills OL, Marzban S, Zager JS, Sondak VK, Messina JL. Sentinel node biopsy in atypical melanocytic neoplasms in childhood: a single institution experience in 24 patients. J Cutan Pathol. 2012;39(3):331-336.CrossRefPubMed
17.
18.
Moore-Olufemi S, Herzog C, Warneke C, et al. Outcomes in pediatric melanoma: comparing prepubertal to adolescent pediatric patients. Ann Surg. 2011;253(6):1211-1215.CrossRefPubMed
19.
Palmer PE 3rd, Warneke CL, Hayes-Jordan AA, et al. Complications in the surgical treatment of pediatric melanoma. J Pediatr Surg. 2013;48(6):1249-1253.CrossRefPubMed
20.
Butter A, Hui T, Chapdelaine J, Beaunoyer M, Flageole H, Bouchard S. Melanoma in children and the use of sentinel lymph node biopsy. J Pediatr Surg. 2005;40(5):797-800.CrossRefPubMed
21.
Downard CD, Rapkin LB, Gow KW. Melanoma in children and adolescents. Surg Oncol. 2007;16(3):215-220.CrossRefPubMed
22.
Sondak VK, Taylor JM, Sabel MS, et al. Mitotic rate and younger age are predictors of sentinel lymph node positivity: lessons learned from the generation of a probabilistic model. Ann Surg Oncol. 2004;11(3):247-258.CrossRefPubMed
23.
Navid F, Furman WL, Fleming M, et al. The feasibility of adjuvant interferon alpha-2b in children with high-risk melanoma. Cancer. 2005;103(4):780-787.CrossRefPubMed
24.
Tcheung WJ, Marcello JE, Puri PK, Abernethy AP, Nelson KC. Evaluation of 39 cases of pediatric cutaneous head and neck melanoma. J Am Acad Dermatol. 2011;65(2):e37-42.CrossRefPubMed
25.
Mu E, Lange JR, Strouse JJ. Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma. Cancer. 2012;118(10):2700-2707.CrossRefPubMed
26.
Ferrari A, Bisogno G, Cecchetto G, et al. Cutaneous melanoma in children and adolescents: the Italian rare tumors in pediatric age project experience. J Pediatr. 2014;164(2):376-382.e1-2.
27.
Mills O, Messina JL. Pediatric melanoma: a review. Cancer Control. 2009;16(3):225-233.PubMed
28.
Schmocker RK, Caretta-Weyer H, Weiss JM, et al. Determining breast cancer axillary surgery within the surveillance epidemiology and end results-Medicare database. J Surg Oncol. 2014;109(8):756-759.CrossRefPubMedPubMedCentral
29.
Howman-Giles R, Uren RF, Thompson J. Sentinel lymph node biopsy in pediatric and adolescent patients: a proven technique. Ann Surg. 2014;259(6):e86.CrossRefPubMed
30.
Dall’Igna P, De Corti F, Alaggio R, Cecchetto G. Sentinel node biopsy in pediatric patients: the experience in a single institution. Eur J Pediatr Surg.2014;24(6):482-487.CrossRefPubMed
31.
Joosse A, de Vries E, Eckel R, et al. Gender differences in melanoma survival: female patients have a decreased risk of metastasis. J Invest Dermatol. 2011;131(3):719-726.CrossRefPubMed
32.
Jukic DM, Rao UN, Kelly L, et al. Microrna profiling analysis of differences between the melanoma of young adults and older adults. J Transl Med. 2010;8:27.CrossRefPubMedPubMedCentral
33.
Daniotti M, Ferrari A, Frigerio S, et al. Cutaneous melanoma in childhood and adolescence shows frequent loss of INK4A and gain of KIT. J Invest Dermatol. 2009;129(7):1759-1768.CrossRefPubMed
34.
Lu C, Zhang J, Nagahawatte P, et al. The genomic landscape of childhood and adolescent melanoma. J Invest Dermatol. 2015;135(3):816-823.CrossRefPubMed
Metadata
Title
Pediatric and Adolescent Melanoma: A National Cancer Data Base Update
Authors
Patrick D. Lorimer, MD
Richard L. White, MD
Kendall Walsh, BA
Yimei Han, MS
Russell C. Kirks, MD
James Symanowski, PhD
Meghan R. Forster, MD
Terry Sarantou, MD
Jonathan C. Salo, MD
Joshua S. Hill, MD
Publication date
01-11-2016
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 12/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-016-5349-2

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