Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 7/2016

01-07-2016 | Bone and Soft Tissue Sarcomas

Abdominal Desmoid Tumors: Hands Off?

Authors: Danique L. M. van Broekhoven, MD, Dirk J. Grunhagen, MD, PhD, Cornelis Verhoef, MD, PhD

Published in: Annals of Surgical Oncology | Issue 7/2016

Login to get access

Excerpt

The reported incidence of desmoid tumors (DT) seems to increase from about two cases per million people in 1993 to about five cases per million people in 2013.1 Because it lacks the ability to metastasize, a desmoid tumor is classified as a benign disorder. Nevertheless, the sequelae of this disease and the applied treatments may be underlined by the fact that patients with familial adenomatous polyposis (FAP) may die from the consequences of DT. Moreover, substantial morbidity due to invasive growth is frequently seen. Because of the poor understanding of the natural history of the disease, its tumor biology, and the lack of randomized studies comparing different treatment options, the recommended treatment options vary widely depending on tumor aggressiveness, location, patient wish, and preferences of the treating physicians. …
Literature
1.
van Broekhoven DL, Grünhagen DJ, den Bakker MA, van Dalen T, Verhoef C. Time trends in the incidence and treatment of extra-abdominal and abdominal aggressive fibromatosis: a population-based study. Ann Surg Oncol. 2015;22(9):2817–23.CrossRefPubMedPubMedCentral
2.
Salas S, Dufresne A, Bui B, Blay JY, Terrier P, Ranchere-Vince D, et al. Prognostic factors influencing progression-free survival determined from a series of sporadic desmoid tumors: a wait-and-see policy according to tumor presentation. J Clin Oncol. 2011;29:3553–8.CrossRefPubMed
3.
Fiore M, Rimareix F, Mariani L, Domont J, Collini P, Le Pechoux C, et al. Desmoid-type fibromatosis: a front-line conservative approach to select patients for surgical treatment. Ann Surg Oncol. 2009;16:2587–93.CrossRefPubMed
4.
Baumert BG, Spahr MO, Von Hochstetter A, Beauvois S, Landmann C, Fridrich K et al. The impact of radiotherapy in the treatment of desmoid tumours. An international survey of 110 patients. A study of the Rare Cancer Network. Radiat Oncol. 2007;2:12.CrossRefPubMedPubMedCentral
5.
Mankin HJ, Hornicek FJ, Springfield DS. Extra-abdominal desmoid tumors: a report of 234 cases. J Surg Oncol. 2010;102:380–4.CrossRefPubMed
6.
Lev D, Kotilingam D, Wei C, Ballo MT, Zagars GK, Pisters PWT, et al. Optimizing treatment of desmoid tumors. J Clin Oncol. 2007;25:1785–91.CrossRefPubMed
7.
Huang K, Fu H, Shi YQ, Zhou Y, Du CY. Prognostic factors for extra-abdominal and abdominal wall desmoids: a 20-year experience at a single institution. J Surg Oncol. 2009;100:563–9.CrossRefPubMed
8.
Guadagnolo BA, Zagars GK, Ballo MT. Long-term outcomes for desmoid tumors treated with radiation therapy. Int J Radiat Oncol Biol Phys. 2008;71:441–7.CrossRefPubMed
9.
van Broekhoven DL, Verhoef C, Elias SG, Witkamp AJ, van Gorp JM, van Geel BA, et al. Local recurrence after surgery for primary extra-abdominal desmoid-type fibromatosis. Br J Surg. 2013;100:1214–9.CrossRefPubMed
10.
Stoeckle E, Coindre JM, Longy M, Binh MB, Kantor G, Kind M, et al. A critical analysis of treatment strategies in desmoid tumours: a review of a series of 106 cases. Eur J Surg Oncol. 2009;35:129–34.CrossRefPubMed
11.
Gluck I, Griffith KA, Biermann JS, Feng FY, Lucas DR, Ben-Josef E. Role of radiotherapy in the management of desmoid tumors. Int J Radiat Oncol Biol Phys. 2011;80:787–92.CrossRefPubMed
12.
Crago AM, Denton B, Salas S, Dufresne A, Mezhir JJ, Hameed M, et al. A prognostic nomogram for prediction of recurrence in desmoid fibromatosis. Ann Surg. 2013;258:347–53.CrossRefPubMedPubMedCentral
13.
Ballo MT, Zagars GK, Pollack A, Pisters PWT, Pollack RA. Desmoid tumor: prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy. J Clin Oncol. 1999;17:158–67.PubMed
14.
Keus RB, Nout RA, Blay JY, de Jong JM, Hennig I, Saran F, et al. Results of a phase II pilot study of moderate dose radiotherapy for inoperable desmoid-type fibromatosis—an EORTC STBSG and ROG study (EORTC 62991-22998). Ann Oncol. 2013;24:2672–6.CrossRefPubMed
15.
van Broekhoven DL, Deroose JP, Bonvalot S, Gronchi A, Grünhagen DJ, Eggermont AM, et al. Isolated limb perfusion using tumour necrosis factor α and melphalan in patients with advanced aggressive fibromatosis. Br J Surg. 2014;101:1674–80.CrossRefPubMed
16.
17.
Burtenshaw SM, Cannell AJ, McAlister ED, Siddique S, Kandel R, Blackstein ME, et al. Toward observation as first-line management in abdominal desmoid tumors. Ann Surg Oncol. doi:10.​1245/​s10434-016-5159-6.
18.
Melis M, Zager JS, Sondak VK. Multimodality management of desmoid tumors: how important is a negative surgical margin? J Surg Oncol. 2008;98:594–602.CrossRefPubMed
19.
Phillips SR, A’Hern R, Thomas JM. Aggressive fibromatosis of the abdominal wall, limbs and limb girdles. Br J Surg. 2004;91:1624–9.CrossRefPubMed
20.
Middleton SB, Phillips RK. Surgery for large intra-abdominal desmoid tumors: report of four cases. Dis Colon Rectum. 2000;43:1759–62.CrossRefPubMed
21.
Wilkinson MJ, Fitzgerald JE, Thomas JM, Hayes AJ, Strauss DC. Surgical resection for non-familial adenomatous polyposis–related intra-abdominal fibromatosis. Br J Surg. 2012;99:706–13.CrossRefPubMed
22.
Robanus-Maandag E, Bosch C, Amini-Nik S, Knijnenburg J, Szuhai K, Cervera P, et al. Familial adenomatous polyposis–associated desmoids display significantly more genetic changes than sporadic desmoids. PLoS One. 2011;6:e24354.CrossRefPubMedPubMedCentral
23.
Huss S, Nehles J, Binot E, Wardelmann E, Mittler J, Kleine MA, et al. β-Catenin (CTNNB1) mutations and clinicopathological features of mesenteric desmoid-type fibromatosis. Histopathology. 2013;62:294–304.CrossRefPubMed
24.
Lazar AJ, Tuvin D, Hajibashi S, Habeeb S, Bolshakov S, Mayordomo-Aranda E, et al. Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol. 2008;173:1518–27.CrossRefPubMedPubMedCentral
25.
Bo N, Wang D, Wu B, Chen L, Ma R. Analysis of β-catenin expression and exon 3 mutations in pediatric sporadic aggressive fibromatosis. Pediatr Dev Pathol. 2012;15:173–8.CrossRefPubMed
26.
van Broekhoven DL, Verhoef C, Grünhagen DJ, van Gorp JM, den Bakker MA, Hinrichs JW, et al. Prognostic falue of CTNNB1 gene mutation in primary sporadic aggressive fibromatosis. Ann Surg Oncol. 2015;22:1464–70.CrossRefPubMed
27.
Fiore M, Coppola S, Cannell AJ, Colombo C, Bertagnolli MM, George S, et al. Desmoid-type fibromatosis and pregnancy: a multi-institutional analysis of recurrence and obstetric risk. Ann Surg. 2014;259:973–8.CrossRefPubMed
28.
van Broekhoven DLM, Grünhagen DJ, van Dalen T, et al. Tailored beta-catenin mutational apporoach in extra-abdominal sporadic desmoid-type fibromatosis patients without therapeutic intervention. An Italian and Dutch initiative. BMC Cancer., submitted.
29.
Kasper B, Baumgarten C, Bonvalot S, Haas R, Haller F, Hohenberger P, et al. Management of sporadic desmoid-type fibromatosis: a European consensus approach based on patients’ and professionals’ expertise—a sarcoma patients EuroNet and European Organisation for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group initiative. Eur J Cancer. 2015;51:127–36.CrossRefPubMed
30.
Fletcher CDM, Bridge JA, Hogendoorn P, Mertens F. WHO classification of tumours of soft tissue and bone. 4th ed. Geneva: World Health Organization; 2013.
31.
Church J, Berk T, Boman BM, et al. Staging intra-abdominal desmoid tumors in familial adenomatous polyposis: a search for a uniform approach to a troubling disease. Dis Colon Rectum. 2005;48:1528–34.CrossRefPubMed
Metadata
Title
Abdominal Desmoid Tumors: Hands Off?
Authors
Danique L. M. van Broekhoven, MD
Dirk J. Grunhagen, MD, PhD
Cornelis Verhoef, MD, PhD
Publication date
01-07-2016
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 7/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-016-5160-0

Other articles of this Issue 7/2016

Annals of Surgical Oncology 7/2016 Go to the issue

Colorectal Cancer

Regional Lymph Nodes Status and Ratio of Metastatic to Examined Lymph Nodes Correlate with Survival in Stage IV Colorectal Cancer

Gynecologic Oncology

Impact of Robotic Platforms on Surgical Approach and Costs in the Management of Morbidly Obese Patients with Newly Diagnosed Uterine Cancer

Healthcare Policy and Outcomes

A Comprehensive Program for the Enhancement of Accrual to Clinical Trials

Breast Oncology

Is Sentinel Lymph Node Biopsy Indicated at Completion Mastectomy for Ductal Carcinoma In Situ?

Healthcare Policy and Outcomes

Health-Related Quality of Life After Pancreatectomy: Results From a Randomized Controlled Trial

Colorectal Cancer

Mixed Adeno-neuroendocrine Carcinoma: An Aggressive Clinical Entity