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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 7/2016

Open Access 01-07-2016 | Gynecologic Oncology

Impact of Indocyanine Green for Sentinel Lymph Node Mapping in Early Stage Endometrial and Cervical Cancer: Comparison with Conventional Radiotracer 99mTc and/or Blue Dye

Authors: Alessandro Buda, MD, Cinzia Crivellaro, MD, Federica Elisei, MD, Giampaolo Di Martino, MD, Luca Guerra, MD, Elena De Ponti, PhD, Marco Cuzzocrea, MD, Daniela Giuliani, MD, Federica Sina, MD, Sonia Magni, MD, Claudio Landoni, MD, Rodolfo Milani, MD

Published in: Annals of Surgical Oncology | Issue 7/2016

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Abstract

Purpose

To compare the detection rate (DR) and bilateral optimal mapping (OM) of sentinel lymph nodes (SLNs) in women with endometrial and cervical cancer using indocyanine green (ICG) versus the standard technetium-99m radiocolloid (99mTc) radiotracer plus methylene or isosulfan blue, or blue dye alone.

Methods

From October 2010 to May 2015, 163 women with stage I endometrial or cervical cancer (118 endometrial and 45 cervical cancer) underwent SLN mapping with 99mTc with blue dye, blue dye alone, or ICG. DR and bilateral OM of ICG were compared respectively with the results obtained using the standard 99mTc radiotracer with blue dye, or blue dye alone.

Results

SLN mapping with 99mTc radiotracer with blue dye was performed on 77 of 163 women, 38 with blue dye only and 48 with ICG. The overall DR of SLN mapping was 97, 89, and 100 % for 99mTc with blue dye, blue dye alone, and ICG, respectively. The bilateral OM rate for ICG was 85 %—significantly higher than the 58 % obtained with 99mTc with blue dye (p = 0.003) and the 54 % for blue dye (p = 0.001). Thirty-one women (19 %) had positive SLNs. Sensitivity and negative predictive value of SLN were 100 % for all techniques.

Conclusions

SLNs mapping using ICG demonstrated higher DR compared to other modalities. In addition, ICG was significantly superior to 99mTc with blue dye in terms of bilateral OM in women with early stage endometrial and cervical cancer. The higher number of bilateral OM may consequently reduce the overall number of complete lymphadenectomies, reducing the duration and additional costs of surgical treatment.
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Metadata
Title
Impact of Indocyanine Green for Sentinel Lymph Node Mapping in Early Stage Endometrial and Cervical Cancer: Comparison with Conventional Radiotracer 99mTc and/or Blue Dye
Authors
Alessandro Buda, MD
Cinzia Crivellaro, MD
Federica Elisei, MD
Giampaolo Di Martino, MD
Luca Guerra, MD
Elena De Ponti, PhD
Marco Cuzzocrea, MD
Daniela Giuliani, MD
Federica Sina, MD
Sonia Magni, MD
Claudio Landoni, MD
Rodolfo Milani, MD
Publication date
01-07-2016
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 7/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-015-5022-1

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