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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2015

01-12-2015 | Thoracic Oncology

Sarcopenia is a Predictor of Postoperative Respiratory Complications in Patients with Esophageal Cancer

Authors: Satoshi Ida, MD, PhD, Masayuki Watanabe, MD, PhD, FACS, Naoya Yoshida, MD, PhD, FACS, Yoshifumi Baba, MD, PhD, Naoki Umezaki, MD, Kazuto Harada, MD, Ryuichi Karashima, MD, Yu Imamura, MD, PhD, Shiro Iwagami, MD, PhD, FACS, Hideo Baba, MD, PhD, FACS

Published in: Annals of Surgical Oncology | Issue 13/2015

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Abstract

Background

Depletion of skeletal muscle mass (sarcopenia) indicates a poor prognosis for patients with several kinds of cancer, but it remains unclear whether esophageal squamous cell carcinoma (ESCC) is among these cancers. The aim of this study was to clarify the relationship between sarcopenia and postoperative outcome in patients with ESCC treated by esophagectomy.

Methods

Skeletal muscle mass was assessed in 138 patients who underwent esophagectomy from August 2009 to May 2014. A multifrequency bioelectrical impedance analysis (InBody 720; Biospace, Tokyo, Japan) was used to assess skeletal muscle mass just before surgery. Postoperative complications were graded according to the Clavien–Dindo classification, and univariate and multivariate analyses were performed for postoperative respiratory complications.

Results

Sarcopenia was determined in 61 patients (44.2 %). Preoperative pulmonary function was significantly lower and the rate of respiratory complications significantly higher in the sarcopenia group than in the non-sarcopenia group (p < 0.01). For other complications, the differences were not significant. Multivariate analysis showed that sarcopenia [odds ratio (OR) 5.82; p = 0.0001] and longer operation time (OR 3.09; p = 0.04) were risk factors for the occurrence of respiratory complications.

Conclusions

Sarcopenia may be a predictor of pulmonary complications after esophagectomy. Further analysis is needed to clarify whether nutritional intervention improves skeletal muscle mass and thus contributes to reducing postoperative respiratory complications in sarcopenic patients.
Appendix
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Metadata
Title
Sarcopenia is a Predictor of Postoperative Respiratory Complications in Patients with Esophageal Cancer
Authors
Satoshi Ida, MD, PhD
Masayuki Watanabe, MD, PhD, FACS
Naoya Yoshida, MD, PhD, FACS
Yoshifumi Baba, MD, PhD
Naoki Umezaki, MD
Kazuto Harada, MD
Ryuichi Karashima, MD
Yu Imamura, MD, PhD
Shiro Iwagami, MD, PhD, FACS
Hideo Baba, MD, PhD, FACS
Publication date
01-12-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 13/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-015-4559-3

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