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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 7/2015

01-07-2015 | Breast Oncology

Second Axillary Sentinel Lymph Node Biopsy for Breast Tumor Recurrence: Experience of the European Institute of Oncology

Authors: M. Intra, MD, G. Viale, MD, J. Vila, MD, C. M. Grana, MD, A. Toesca, MD, O. Gentilini, MD, V. Galimberti, MD, P. Veronesi, MD, A. Luini, MD, N. Rotmensz, MSc, V. Bagnardi, MSc, D. Mattar, MD, M. Colleoni, MD

Published in: Annals of Surgical Oncology | Issue 7/2015

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Abstract

Purpose

This retrospective study aimed to determine the feasibility, accuracy, and recurrence rates of lymphoscintigraphy and the new sentinel lymph node biopsy (SLNB) for patients with ipsilateral breast tumor recurrences who were treated previously with conservative surgery and had negative SLNB results.

Methods

The study was conducted at the European Institute of Oncology in Milan and included 212 patients with the diagnosis of operable local breast cancer recurrence. They had been treated previously with conservative surgery and showed negative SLNB results. They subsequently underwent additional breast surgery and a second SLNB between May 2001 and December 2011.

Results

Preoperative lymphoscintigraphy demonstrated at least one new axillary sentinel lymph node (SLN) in 207 patients (97.7 %), whereas no drainage was observed in five patients (2.3 %). One or more SLNs were surgically removed from 196 of the 207 patients. Isolation of SLNs from the remaining 11 patients could not be accomplished. The success rate for the SLNB was 92.5 %. Extra-axillary drainage pathways were visualized in 17 patients (8 %). The annual axillary recurrence rate after a median follow-up period of 48 months was 0.8 %, and the cumulative incidence of axillary recurrence at 5 years was 3.9 %.

Conclusions

A second SLNB should be considered for patients with operable local breast tumor recurrence who underwent conservative surgery and had negative SLNB results. The procedure is technically feasible and accurate for selected patients.
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Metadata
Title
Second Axillary Sentinel Lymph Node Biopsy for Breast Tumor Recurrence: Experience of the European Institute of Oncology
Authors
M. Intra, MD
G. Viale, MD
J. Vila, MD
C. M. Grana, MD
A. Toesca, MD
O. Gentilini, MD
V. Galimberti, MD
P. Veronesi, MD
A. Luini, MD
N. Rotmensz, MSc
V. Bagnardi, MSc
D. Mattar, MD
M. Colleoni, MD
Publication date
01-07-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 7/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-014-4282-5

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