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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2015

01-04-2015 | Head and Neck Oncology

Elective Neck Dissection in Patients With Head and Neck Adenoid Cystic Carcinoma: An International Collaborative Study

Authors: Moran Amit, MD, Shorook Na’ara, MD, Kanika Sharma, MD, Naomi Ramer, DMD, Ilana Ramer, MD, Abib Agbetoba, MD, Joelle Glick, MD, Xinjie Yang, MD, PhD, Delin Lei, MD, Kristine Bjoerndal, MD, PhD, Christian Godballe, MD, PhD, Thomas Mücke, MD, DDS, Wolff Klaus-Dietrich, MD, DDS, PhD, André M. Eckardt, MD, DDS, PhD, Chiara Copelli, MD, Enrico Sesenna, MD, Frank Palmer, Ian Ganly, MD, Ziv Gil, MD, PhD

Published in: Annals of Surgical Oncology | Issue 4/2015

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Abstract

Background

Adenoid cystic carcinoma (ACC) accounts for 3–5 % of all head and neck malignancies. Investigations of outcomes from elective neck dissection (END) for patients with ACC are sparse. This study aimed to assess the impact of END on the survival of patients with ACC.

Methods

This retrospective multicentered study investigated 270 patients who underwent neck dissection. A multivariate analysis assessed associations of clinical and histopathologic characteristics with survival outcomes.

Results

The primary tumor sites included the oral cavity in 250 patients (55 %), the major salivary glands in 133 patients (29 %), the sinonasal mucosa in 68 patients (15 %), and the larynx in six patients (1 %). The overall rate of occult nodal metastases among the patients who underwent END was 17 % (38/226). The highest incidence of occult nodal metastases was with the oral cavity (66 %). The 5-year overall survival (72 and 79 % for patients with or without END, respectively) and disease-specific survival (74 and 81 % for patients with or without END, respectively) were similar in the two groups. The subgroup analysis of patients according to the primary site showed no significant impact of END on outcome. In the multivariate analysis, primary site, T classification, and N classification were the only variables associated with outcome.

Conclusions

The incidence of occult neck metastases among patients with ACC is 17 %. The highest incidence of occult metastases is with the oral cavity. Statistical analysis showed no survival advantage for patients who underwent END compared with those who did not.
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Literature
1.
Bhayani MK, Yener M, El-Naggar A, et al. Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer 2012;118(11):2872-8.CrossRefPubMed
2.
Spiro RH, Alfonso AE, Farr HW, Strong EW. Cervical node metastasis from epidermoid carcinoma of the oral cavity and oropharynx. A critical assessment of current staging. American Journal of Surgery 1974;128(4):562-7.CrossRefPubMed
3.
Shah JP. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. American Journal of Surgery 1990;160(4):405-9.CrossRefPubMed
4.
Snow GB, van den Brekel MW, Leemans CR, Patel P. Surgical management of cervical lymph nodes in patients with oral and oropharyngeal cancer. Recent results in cancer research Fortschritte der Krebsforschung Progres dans les recherches sur le cancer 1994;134:43-55.PubMed
5.
Bernier J, Domenge C, Ozsahin M, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 2004;350(19):1945-52.CrossRefPubMed
6.
Cooper JS, Pajak TF, Forastiere AA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 2004;350(19):1937-44.CrossRefPubMed
7.
Robbins KT, Shaha AR, Medina JE, et al. Consensus statement on the classification and terminology of neck dissection. Archives of otolaryngolog 2008;134(5):536-8.CrossRef
8.
Pn g. Guidelines for the examination and reporting of head and neck cancer specimens. Ed.LEEDS: Yorkshire Cancer Network 2007 1-12.
9.
Kaplan EL, Meier P. Non-parametric estimation from incomplete observation. J Am Stat Assoc 1958;53:457-481.
10.
Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemotherapy Reports Part 1 1966;50(3):163-70.
11.
Cox DR. Regression models and life-tables. J R Stat Soc 1972;34:187-220.
12.
Gil Z, Patel SG, Singh B, et al. Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: an international collaborative study. Cancer 2007;110(5):1033-41.CrossRefPubMed
13.
Terhaard CH, Lubsen H, Van der Tweel I, et al. Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head & Neck 2004;26(8):681-92.CrossRefPubMed
14.
Balamucki CJ, Amdur RJ, Werning JW, et al. Adenoid cystic carcinoma of the head and neck. American Journal of Otolaryngology 2012;33(5):510-8.CrossRef
15.
Min R, Siyi L, Wenjun Y, et al. Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases. International Journal of Oral and Maxillofacial Surgery 2012;41(8):952-7.CrossRefPubMed
16.
Wei WI, Ferlito A, Rinaldo A, et al. Management of the N0 neck--reference or preference. Oral Oncology 2006;42(2):115-22.CrossRef
17.
Pitman KT. Rationale for elective neck dissection. American Journal of Otolaryngology 2000;21(1):31-7.CrossRef
18.
Adachi M, Mitsudo K, Yamamoto N, et al. Chemoradiotherapy for maxillary sinus adenoid cystic carcinoma using superselective intra-arterial infusion via a superficial temporal artery. Head & Neck 2013;35(3):E89-93.CrossRefPubMed
19.
Verweij J, de Mulder PH, de Graeff A, et al. Phase II study on mitoxantrone in adenoid cystic carcinomas of the head and neck. EORTC Head and Neck Cancer Cooperative Group. Annals of Oncology : Official Journal of the European Society for Medical Oncology 1996;7(8):867-9.CrossRef
20.
Budd GT, Groppe CW. Adenoid cystic carcinoma of the salivary gland. Sustained complete response to chemotherapy. Cancer 1983;51(4):589-90.
21.
Amit M, Binenbaum Y, Sharma K, et al. Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study.2013 Head Neck 36(7):998-1004.CrossRefPubMed
Metadata
Title
Elective Neck Dissection in Patients With Head and Neck Adenoid Cystic Carcinoma: An International Collaborative Study
Authors
Moran Amit, MD
Shorook Na’ara, MD
Kanika Sharma, MD
Naomi Ramer, DMD
Ilana Ramer, MD
Abib Agbetoba, MD
Joelle Glick, MD
Xinjie Yang, MD, PhD
Delin Lei, MD
Kristine Bjoerndal, MD, PhD
Christian Godballe, MD, PhD
Thomas Mücke, MD, DDS
Wolff Klaus-Dietrich, MD, DDS, PhD
André M. Eckardt, MD, DDS, PhD
Chiara Copelli, MD
Enrico Sesenna, MD
Frank Palmer
Ian Ganly, MD
Ziv Gil, MD, PhD
Publication date
01-04-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 4/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-014-4106-7

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