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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 11/2014

01-10-2014 | Colorectal Cancer

Systematic Review of FDG-PET Prediction of Complete Pathological Response and Survival in Rectal Cancer

Authors: Sameer Memon, FRACS, A. Craig Lynch, MMedSci, FRACS, FCSSANZ, FASCRS (INT), Timothy Akhurst, MD, MBBS, Samuel Y. Ngan, MBBS, Satish K. Warrier, MS, FRACS, Michael Michael, MD, FRACP, Alexander G. Heriot, MD FRCS (Gen.), FRCSEd, FRACS

Published in: Annals of Surgical Oncology | Issue 11/2014

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Abstract

Background

Advances in the management of rectal cancer have resulted in an increased application of multimodal therapy with the aim of tailoring therapy to individual patients. Complete pathological response (pCR) is associated with improved survival and may be potentially managed without radical surgical resection. Over the last decade, there has been increasing interest in the ability of functional imaging to predict complete response to treatment. The aim of this review was to assess the role of 18F-flurordeoxyglucose positron emission tomography (FDG-PET) in prediction of pCR and prognosis in resectable locally advanced rectal cancer.

Methods

A search of the MEDLINE and Embase databases was conducted, and a systematic review of the literature investigating positron emission tomography (PET) in the prediction of pCR and survival in rectal cancer was performed.

Results

Seventeen series assessing PET prediction of pCR were included in the review. Seven series assessed postchemoradiation SUVmax, which was significantly different between response groups in all six studies that assessed this. Nine series assessed the response index (RI) for SUVmax, which was significantly different between response groups in seven series. Thirteen studies investigated PET response for prediction of survival. Metabolic complete response assessed by SUV2max or visual response and RISUVmax showed strong associations with disease-free survival (DFS) and overall survival (OS).

Conclusion

SUV2max and RISUVmax appear to be useful FDG-PET markers for prediction of pCR and these parameters also show strong associations with DFS and OS. FDG-PET may have a role in outcome prediction in patients with advanced rectal cancer.
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Metadata
Title
Systematic Review of FDG-PET Prediction of Complete Pathological Response and Survival in Rectal Cancer
Authors
Sameer Memon, FRACS
A. Craig Lynch, MMedSci, FRACS, FCSSANZ, FASCRS (INT)
Timothy Akhurst, MD, MBBS
Samuel Y. Ngan, MBBS
Satish K. Warrier, MS, FRACS
Michael Michael, MD, FRACP
Alexander G. Heriot, MD FRCS (Gen.), FRCSEd, FRACS
Publication date
01-10-2014
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 11/2014
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-014-3753-z

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