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01-05-2014 | Regional Cancer Therapies

Aggressive Locoregional Surgical Therapy for Gastric Peritoneal Carcinomatosis

Authors: Deepa Magge, MD, Mazen Zenati, MD, PhD, Arun Mavanur, MD, Joshua Winer, MD, Lekshmi Ramalingam, MD, Heather Jones, MPA-C, Amer Zureikat, MD, Matthew Holtzman, MD, Kenneth Lee, MD, Steven Ahrendt, MD, James Pingpank, MD, Herbert J. Zeh, MD, David L. Bartlett, MD, Haroon A. Choudry, MD

Published in: Annals of Surgical Oncology | Issue 5/2014

Abstract

Background

Peritoneal carcinomatosis from gastric cancer (GPC) responds poorly to systemic chemotherapy. Limited published data demonstrate improved outcomes after aggressive locoregional therapies. We assessed the efficacy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) in GPC.

Methods

We prospectively analyzed 23 patients with GPC undergoing CRS/HIPEC between 2001 and 2010. Kaplan–Meier survival curves and multivariate Cox regression models identified prognostic factors affecting oncologic outcomes.

Results

CRS/HIPEC was performed for synchronous GPC in 20 patients and metachronous GPC in 3 patients. Adequate CRS was achieved in 22 patients (CC-0 = 17; CC-1 = 5) and median peritoneal cancer index was 10.5. Most patients received preoperative chemotherapy (83 %) and total gastrectomy (78 %). Pathology revealed diffuse histology (65 %), signet cells (65 %) and LN involvement (64 %). Major postoperative morbidity occurred in 12 patients, with 1 in-hospital mortality at postoperative day 66. With median follow-up of 52 months, median overall survival (OS) was 9.5 months (95 % confidence interval 4.7–17.3), with 1- and 3- year OS rates of 50 and 18 %. Median progression-free survival (PFS) was 6.8 months (95 % confidence interval 3.9–14.6). In a multivariate Cox regression model, male gender [hazard ratio (HR) 6.3], LN involvement (HR 1.2), residual tumor nodules (HR 2.4), and >2 anastomoses (HR 2.8) were joint significant predictors of poor OS (χ ² = 18.2, p = 0.001), while signet cells (HR 8.9), anastomoses >2 (HR 5.5), and male gender (HR 2.4) were joint significant predictors of poor progression (χ ² = 16.3, p = 0.001).

Conclusions

Aggressive CRS/HIPEC for GPC may confer a survival benefit in select patients with limited lymph node involvement and completely resectable disease requiring less extensive visceral resections.

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Title: Aggressive Locoregional Surgical Therapy for Gastric Peritoneal Carcinomatosis
Authors: Deepa Magge, MD
Mazen Zenati, MD, PhD
Arun Mavanur, MD
Joshua Winer, MD
Lekshmi Ramalingam, MD
Heather Jones, MPA-C
Amer Zureikat, MD
Matthew Holtzman, MD
Kenneth Lee, MD
Steven Ahrendt, MD
James Pingpank, MD
Herbert J. Zeh, MD
David L. Bartlett, MD
Haroon A. Choudry, MD
Publication date: 01-05-2014
Publisher: Springer US
Published in: Annals of Surgical Oncology / Issue 5/2014
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-013-3327-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Aggressive Locoregional Surgical Therapy for Gastric Peritoneal Carcinomatosis

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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