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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 9/2013

01-09-2013 | Breast Oncology

Supporting Trials for Primary Tumor Resection in Stage IV Breast Cancer is Paramount

Authors: Elly Harris, MD, Mitchel Barry, MD, FRCSI, Malcolm R. Kell, FRCSI

Published in: Annals of Surgical Oncology | Issue 9/2013

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Excerpt

A key motivation behind publishing our meta-analysis to determine whether surgical resection of the primary tumor in the setting of stage IV breast cancer affects survival was to reassure clinicians and their patients that entering patients into the one of the ongoing six randomized trials—or indeed into the prospective registry study led by T. A. King—was safe and would not compromise patient care. Failure to accrue the appropriate number of patients can be detrimental to any randomized trial, and therefore some level of evidence, albeit biased and with recognized limitations, is required to support trial accrual. …
Literature
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Hazard HW, Gorla SR, Scholtens D, Kiel K, Gradishar WJ, Khan SA. Surgical resection of the primary tumor, chest wall control, and survival in women with metastatic breast cancer. Cancer. 2008;113:2011–9.PubMedCrossRef
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Harris E, Barry M, Kell MR. Meta-analysis to determine if surgical resection of the primary tumour in the setting of stage IV breast cancer impacts on survival. Ann Surg Oncol. 2013. doi:10.​1245/​s10434-013-2998-2.
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Perez CG, Khan SA. Local therapy for the primary breast tumor in women with metastatic disease. Clin Adv Hematol Oncol. 2011;9:112–9.PubMed
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Petrelli F, Barni S. Surgery of primary tumours in stage IV breast cancer: an updated meta-analysis of published studies with meta-regression. Med Oncol. 2012;29:3282–90.PubMedCrossRef
Metadata
Title
Supporting Trials for Primary Tumor Resection in Stage IV Breast Cancer is Paramount
Authors
Elly Harris, MD
Mitchel Barry, MD, FRCSI
Malcolm R. Kell, FRCSI
Publication date
01-09-2013
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 9/2013
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-013-3098-z

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