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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2012

01-12-2012 | Gynecologic Oncology

The Role of Heated Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer: Hope or Hoax?

Author: Thomas J. Herzog, MD, FACS

Published in: Annals of Surgical Oncology | Issue 13/2012

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Excerpt

The role of heated intraperitoneal chemotherapy (HIPEC) to treat peritoneal-based cancers has been debated for years. Meanwhile papers that advocate the advantages of this modality continue to accrue, but questions regarding efficacy, optimal indications, patient selection, and toxicity remain largely unresolved. This uncertainty for HIPEC benefit is especially acute in ovarian cancer. Is it time for clinicians to incorporate this treatment modality into the care of ovarian cancer patients? If so, then in whom should this aggressive therapy be prescribed, front-line or recurrent disease? In examining the use of this modality, one needs to consider the defining elements that constitute HIPEC therapy. …
Literature
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Hess LM, Benham-Hutchins M, Herzog TJ, Hsu CH, Malone DC, Skrepnek GH, et al. A meta-analysis of the efficacy of intraperitoneal cisplatin for the front-line treatment of ovarian cancer. Int J Gynecol Cancer. 2007;17:561–70.PubMedCrossRef
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Helm CW. The role of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer. Oncologist. 2009;14:683–94.PubMedCrossRef
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Bakrin N, Cotte E, Golfier F, Gilly FN, Freyer G, Helm W, et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for persistent and recurrent advanced ovarian carcinoma: a multicenter, prospective study of 246 patients. Ann Surg Oncol. doi:10.​1245/​s10434-012-2510-4.
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Dovern E, de Hingh IH, Verwaal VJ, van Driel WJ, Nienhuijs SW. Hyperthermic intraperitoneal chemotherapy added to the treatment of ovarian cancer. A review of achieved results and complications. Eur J Gynaecol Oncol. 2010;31:256–61.PubMed
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Mulier S, Claes JP, Dierieck V, Amiel JO, Pahaut JP, Marcelis L, et al. Survival benefit of adding hyperthermic intraperitoneal chemotherapy (HIPEC) at the different time-points of treatment of ovarian cancer: review of evidence. Curr Pharm Des. 2012; May 14 [Epub ahead of print].
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Metadata
Title
The Role of Heated Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer: Hope or Hoax?
Author
Thomas J. Herzog, MD, FACS
Publication date
01-12-2012
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 13/2012
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-012-2521-1

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