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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2012

01-04-2012 | Thoracic Oncology

Comparison between Preoperative Versus Intraoperative Injection of Technetium-99 m Neomannosyl Human Serum Albumin for Sentinel Lymph Node Identification in Early Stage Lung Cancer

Authors: Hyun Koo Kim, MD, PhD, Sungeun Kim, MD, PhD, Ho Kyung Sung, MD, Yun-Sang Lee, PhD, Jae Min Jeong, PhD, Young Ho Choi, MD, PhD

Published in: Annals of Surgical Oncology | Issue 4/2012

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Abstract

Purpose

We aimed to evaluate the results of sentinel lymph node mapping according to injection time (preoperative vs. intraoperative) of technetium-99m neomannosyl human serum albumin (99mTc-MSA) in patients with lung cancer.

Methods

Data of 82 patients (55 men; mean age 62.9 ± 9.3 years) who were candidates for lobectomy with mediastinal lymph node dissection for clinical stage I non–small cell lung cancer were retrospectively reviewed. 99mTc-MSA was administered at the peritumoral region under chest computed tomographic guidance, 1 to 2 h before surgery (preoperation group, n = 48) or soon after thoracotomy (intraoperation group, n = 34).

Results

Patients’ demographic data, except type of operation, did not differ between the two groups. Sentinel lymph nodes were detected in 46 patients (95.8%) in the preoperation group and 33 patients (97.1%) in the intraoperation group (P = .243). The mean number of sentinel nodes per patient was 2.1 in the preoperation group and 2.6 in the intraoperation group (P = .068). No falsely negative sentinel nodes were detected in any of the 17 patients with N1 or N2 disease (0%) in either group. Administration of the intraoperative injection could save additional cost (US$607) and time (70 min) in each patient.

Conclusions

Sentinel node identification using 99mTc-MSA appears to provide similar excellent results in both preoperative and intraoperative injection. Therefore, intraoperative injection of 99mTc-MSA may be preferred as a result of lower cost and less waste of time.
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Metadata
Title
Comparison between Preoperative Versus Intraoperative Injection of Technetium-99 m Neomannosyl Human Serum Albumin for Sentinel Lymph Node Identification in Early Stage Lung Cancer
Authors
Hyun Koo Kim, MD, PhD
Sungeun Kim, MD, PhD
Ho Kyung Sung, MD
Yun-Sang Lee, PhD
Jae Min Jeong, PhD
Young Ho Choi, MD, PhD
Publication date
01-04-2012
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 4/2012
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-011-2130-4

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