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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2012

01-07-2012 | Translational Research and Biomarkers

TNFAIP8 Overexpression: Clinical Relevance to Esophageal Squamous Cell Carcinoma

Authors: Yuni Elsa Hadisaputri, Pharm.D, Tatsuya Miyazaki, MD, PhD, Shigemasa Suzuki, MD, Takehiko Yokobori, MD, PhD, Tsutomu Kobayashi, MD, PhD, Naritaka Tanaka, MD, PhD, Takanori Inose, MD, PhD, Makoto Sohda, MD, PhD, Hiroyuki Kuwano, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2012

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Abstract

Background

Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) is a suppressor of TNF-α mediated apoptosis, and its expression is induced by NF-κB activation. TNFAIP8 expression is significantly increased in various cancer cell lines. A correlation between TNFAIP8 overexpression, cancer progression, and poor prognosis has been described in many reports of human solid cancers.

Methods

To clarify the functional and clinical significance of the cancer progression-related gene, TNFAIP8, in esophageal squamous cell carcinoma (ESCC), we used immunohistochemistry to demonstrate TNFAIP8 expression in ESCC. Next, TNFAIP8 expression was depleted by using siRNA to examine the function of TNFAIP8 in the proliferation and apoptosis induction of ESCC cell lines.

Results

We detected correlations between TNFAIP8 expression and TNM stage (P < 0.001), tumor depth (P = 0.002), lymph node metastasis (P = 0.013), distant metastasis (P = 0.001), lymphatic invasion (P < 0.001), and venous invasion (P < 0.001) among the clinicopathological characteristics of ESCC patients, and high TNFAIP8 expression was found in poor survival. TNFAIP8 depletion was significantly associated with apoptosis induction after cisplatin administration and reduced proliferation.

Conclusions

Our results suggest that TNFAIP8 might be an effective therapeutic target for ESCC in the future.
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Metadata
Title
TNFAIP8 Overexpression: Clinical Relevance to Esophageal Squamous Cell Carcinoma
Authors
Yuni Elsa Hadisaputri, Pharm.D
Tatsuya Miyazaki, MD, PhD
Shigemasa Suzuki, MD
Takehiko Yokobori, MD, PhD
Tsutomu Kobayashi, MD, PhD
Naritaka Tanaka, MD, PhD
Takanori Inose, MD, PhD
Makoto Sohda, MD, PhD
Hiroyuki Kuwano, MD, PhD
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2012
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-011-2097-1

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