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Annals of Surgical Oncology

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01-08-2011 | Head and Neck Oncology

Prognostic Value of Lymph Node Density in Node-Positive Patients with Oral Squamous Cell Carcinoma

Authors: Sang Yoon Kim, MD, Soon Yuhl Nam, MD, Seung-Ho Choi, MD, Kyung-Ja Cho, MD, Jong-Lyel Roh, MD

Published in: Annals of Surgical Oncology | Issue 8/2011

Abstract

Background

Lymph node density (LND) is superior to TNM nodal status in predicting survival after surgery for bladder and other cancers. Little is known, however, about whether LND can predict survival in patients with oral squamous cell carcinoma (OSCC). We therefore evaluated the utility of LND for predicting survival for patients with OSCC and positive nodes (pN+).

Methods

We reviewed the clinical, pathologic, and follow-up data of 211 OSCC patients who underwent surgery. All lymph nodes harvested from neck dissection were carefully examined, with LND calculated as the ratio of positive lymph nodes to total lymph nodes removed. Univariate and multivariate analyses of variables predicting overall survival (OS) and disease-specific survival (DSS) were performed for all patients and in pN+ patients.

Results

Kaplan-Meier analyses showed that the 5-year OS and DSS rates in all patients were 72% and 79%, respectively. Multivariate analysis showed that variables independently prognostic for DSS were T classification (hazard ratio [HR] = 2.97, 95% confidence interval [95% CI] = 1.59–5.57; P = .001), and N classification (HR = 4.91, 95% CI = 2.47–9.75; P < .001). In pN+ patients, univariate analysis showed that T classification, >2 positive nodes, and LND >0.06 (median) were significant predictors of DSS (P < .015 each), and multivariate analysis showed that LND was an independent predictor of DSS (HR = 3.24, 95% CI = 1.61–6.53; P = .001).

Conclusions

LND may be useful in stratifying the likelihood of survival in patients with OSCC.

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Title: Prognostic Value of Lymph Node Density in Node-Positive Patients with Oral Squamous Cell Carcinoma
Authors: Sang Yoon Kim, MD
Soon Yuhl Nam, MD
Seung-Ho Choi, MD
Kyung-Ja Cho, MD
Jong-Lyel Roh, MD
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 8/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-011-1614-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prognostic Value of Lymph Node Density in Node-Positive Patients with Oral Squamous Cell Carcinoma

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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