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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 9/2011

01-09-2011 | Gastrointestinal Oncology

Association of Intra-tumoral Infiltrating Macrophages and Regulatory T Cells Is an Independent Prognostic Factor in Gastric Cancer after Radical Resection

Authors: Bo Wang, PhD, Dazhi Xu, MD, Xingjuan Yu, MD, Tong Ding, PhD, Huilan Rao, MD, Youqing Zhan, MD, Limin Zheng, MD, Lian Li, PhD

Published in: Annals of Surgical Oncology | Issue 9/2011

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Abstract

Background

Macrophages (Mφ) and regulatory T cells (Tregs) are the major components of the inflammatory infiltrate in virtually all tumors. The objective of this study was to investigate the prognostic significance of Mφ and Tregs infiltration in advanced gastric cancer after radical resection.

Methods

CD68+ Mφ and FOXP3+ Tregs were assessed by immunohistochemistry in tissues from 107 patients with surgically advanced gastric cancer. The microlocalization of Mφ and Tregs cells with respect to the development of gastric cancer were given special concern. Prognostic value of normal, peritumoral, and intratumoral Mφ and Tregs densities was evaluated by Kaplan–Meier analysis and Cox regression.

Results

The results showed that the presence of intratumoral CD68+ Mφ was an independent prognostic factor for overall survival (OS) (P = 0.02). Moreover, the combination of high numbers of intratumoral CD68+ Mφ and FOXP3+ Tregs was associated with improved survival (P = 0.041). Five-year OS rate was only 27% for patients with low intratumoral Mφ and intratumoral Tregs compared with 62% for patients with high intratumoral Mφ and intratumoral Tregs. In addition, advanced intestinal-type gastric cancers were more likely to have fewer infiltrating Mφ than diffuse-type cancers (P = 0.024).

Conclusions

Association of intratumoral Mφ and Tregs is a promising independent predictor for survival in advanced gastric cancer. The results suggested that a combination of concomitant stimulation of intratumoral Mφ and Tregs may be an effective strategy for treatment of patients with advanced gastric cancer after radical resection.
Appendix
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Metadata
Title
Association of Intra-tumoral Infiltrating Macrophages and Regulatory T Cells Is an Independent Prognostic Factor in Gastric Cancer after Radical Resection
Authors
Bo Wang, PhD
Dazhi Xu, MD
Xingjuan Yu, MD
Tong Ding, PhD
Huilan Rao, MD
Youqing Zhan, MD
Limin Zheng, MD
Lian Li, PhD
Publication date
01-09-2011
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 9/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-011-1609-3

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