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Published in: Annals of Surgical Oncology 8/2011

01-08-2011 | Breast Oncology

Does a Supplementary Preoperative Breast MRI in Patients with Invasive Lobular Breast Cancer Change Primary and Secondary Surgical Interventions?

Authors: Joerg Heil, MD, Anne Bühler, Michael Golatta, MD, Joachim Rom, MD, Aba Harcos, MD, Anne Schipp, MD, Geraldine Rauch, PhD, Hans Junkermann, MD, Christof Sohn, MD

Published in: Annals of Surgical Oncology | Issue 8/2011

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Abstract

Background

We evaluated whether a supplementary preoperative breast MRI in patients with invasive lobular breast cancer (ILC) has changed number and methods of primary and number of secondary surgical interventions.

Materials and Methods

This was a retrospective controlled single-center analysis of 178 ILC patients. The 2 study groups consisted of 92 patients with breast MRI (MRI group) and of 86 patients without breast MRI (non-MRI group). We investigated the primary and final surgical procedures and factors that influenced the number of secondary surgical interventions.

Results

A total of 40 primary mastectomies (38%) have been performed in the MRI group, compared with 27 (30%) in the non-MRI group (P = .119).There have been more bilateral surgical interventions in the MRI group (14 vs 3 patients; P = .002). The 2 groups did not differ with respect to secondary surgery rates (P = .429). The MRI and non-MRI group were significantly different with respect to age and breast density (P = .003 and P = .002). Yet, both variables seemed not to influence secondary surgery rates (P = .516 and P = .788, respectively).

Conclusions

The implementation of preoperative breast MRI tended to result in more primary mastectomies and bilateral surgeries and did not seem to decrease the secondary surgery rate.
Literature
1.
go back to reference Arpino G, Bardou VJ, Clark GM, Elledge RM. Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome. Breast Cancer Res. 2004;6:R149–56.PubMedCrossRef Arpino G, Bardou VJ, Clark GM, Elledge RM. Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome. Breast Cancer Res. 2004;6:R149–56.PubMedCrossRef
2.
go back to reference Li CI, Anderson BO, Daling JR, Moe RE. Trends in incidence rates of invasive lobular and ductal breast carcinoma. JAMA. 2003;289:1421–4.PubMedCrossRef Li CI, Anderson BO, Daling JR, Moe RE. Trends in incidence rates of invasive lobular and ductal breast carcinoma. JAMA. 2003;289:1421–4.PubMedCrossRef
3.
go back to reference Turnbull L, Brown S, Harvey I, Olivier C, Drew P, Napp V, et al. Comparative effectiveness of MRI in breast cancer (COMICE) trial: a randomised controlled trial. Lancet. 375:563–71. Turnbull L, Brown S, Harvey I, Olivier C, Drew P, Napp V, et al. Comparative effectiveness of MRI in breast cancer (COMICE) trial: a randomised controlled trial. Lancet. 375:563–71.
4.
go back to reference Kneeshaw PJ, Turnbull LW, Smith A, Drew PJ. Dynamic contrast enhanced magnetic resonance imaging aids the surgical management of invasive lobular breast cancer. Eur J Surg Oncol. 2003;29:32–7.PubMedCrossRef Kneeshaw PJ, Turnbull LW, Smith A, Drew PJ. Dynamic contrast enhanced magnetic resonance imaging aids the surgical management of invasive lobular breast cancer. Eur J Surg Oncol. 2003;29:32–7.PubMedCrossRef
5.
go back to reference Quan ML, Sclafani L, Heerdt AS, Fey JV, Morris EA, Borgen PI. Magnetic resonance imaging detects unsuspected disease in patients with invasive lobular cancer. Ann Surg Oncol. 2003;10:1048–53.PubMedCrossRef Quan ML, Sclafani L, Heerdt AS, Fey JV, Morris EA, Borgen PI. Magnetic resonance imaging detects unsuspected disease in patients with invasive lobular cancer. Ann Surg Oncol. 2003;10:1048–53.PubMedCrossRef
6.
go back to reference Bedrosian I, Mick R, Orel SG, Schnall M, Reynolds C, Spitz FR, et al. Changes in the surgical management of patients with breast carcinoma based on preoperative magnetic resonance imaging. Cancer. 2003;98:468–73.PubMedCrossRef Bedrosian I, Mick R, Orel SG, Schnall M, Reynolds C, Spitz FR, et al. Changes in the surgical management of patients with breast carcinoma based on preoperative magnetic resonance imaging. Cancer. 2003;98:468–73.PubMedCrossRef
8.
go back to reference Mann RM, Kuhl CK, Kinkel K, Boetes C. Breast MRI: guidelines from the European Society of Breast Imaging. Eur Radiol. 2008;18:1307–18.PubMedCrossRef Mann RM, Kuhl CK, Kinkel K, Boetes C. Breast MRI: guidelines from the European Society of Breast Imaging. Eur Radiol. 2008;18:1307–18.PubMedCrossRef
10.
go back to reference Solin LJ, Orel SG, Hwang WT, Harris EE, Schnall MD. Relationship of breast magnetic resonance imaging to outcome after breast-conservation treatment with radiation for women with early-stage invasive breast carcinoma or ductal carcinoma in situ. J Clin Oncol. 2008;26:386–91.PubMedCrossRef Solin LJ, Orel SG, Hwang WT, Harris EE, Schnall MD. Relationship of breast magnetic resonance imaging to outcome after breast-conservation treatment with radiation for women with early-stage invasive breast carcinoma or ductal carcinoma in situ. J Clin Oncol. 2008;26:386–91.PubMedCrossRef
11.
go back to reference Mann RM, Hoogeveen YL, Blickman JG, Boetes C. MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature. Breast Cancer Res Treat. 2008;107:1–14.PubMedCrossRef Mann RM, Hoogeveen YL, Blickman JG, Boetes C. MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature. Breast Cancer Res Treat. 2008;107:1–14.PubMedCrossRef
12.
go back to reference Fabre Demard N, Boulet P, Prat X, Charra L, Lesnik A, Taourel P. [Breast MRI in invasive lobular carcinoma: diagnosis and staging]. J Radiol. 2005;86:1027–34.PubMedCrossRef Fabre Demard N, Boulet P, Prat X, Charra L, Lesnik A, Taourel P. [Breast MRI in invasive lobular carcinoma: diagnosis and staging]. J Radiol. 2005;86:1027–34.PubMedCrossRef
13.
go back to reference Schelfout K, Van Goethem M, Kersschot E, Verslegers I, Biltjes I, Leyman P, et al. Preoperative breast MRI in patients with invasive lobular breast cancer. Eur Radiol. 2004;14:1209–16.PubMedCrossRef Schelfout K, Van Goethem M, Kersschot E, Verslegers I, Biltjes I, Leyman P, et al. Preoperative breast MRI in patients with invasive lobular breast cancer. Eur Radiol. 2004;14:1209–16.PubMedCrossRef
14.
go back to reference Diekmann F, Diekmann S, Beljavskaja M, Bick U, Taupitz M, Blohmer JU, et al. [Preoperative MRT of the breast in invasive lobular carcinoma in comparison with invasive ductal carcinoma]. Rofo. 2004;176:544–9.PubMed Diekmann F, Diekmann S, Beljavskaja M, Bick U, Taupitz M, Blohmer JU, et al. [Preoperative MRT of the breast in invasive lobular carcinoma in comparison with invasive ductal carcinoma]. Rofo. 2004;176:544–9.PubMed
15.
go back to reference Berg WA, Gutierrez L, NessAiver MS, Carter WB, Bhargavan M, Lewis RS, et al. Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer. Radiology. 2004;233:830–49.PubMedCrossRef Berg WA, Gutierrez L, NessAiver MS, Carter WB, Bhargavan M, Lewis RS, et al. Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer. Radiology. 2004;233:830–49.PubMedCrossRef
16.
go back to reference Jatoi I, Proschan MA. Randomized trials of breast-conserving therapy versus mastectomy for primary breast cancer: a pooled analysis of updated results. Am J Clin Oncol. 2005;28:289–94.PubMedCrossRef Jatoi I, Proschan MA. Randomized trials of breast-conserving therapy versus mastectomy for primary breast cancer: a pooled analysis of updated results. Am J Clin Oncol. 2005;28:289–94.PubMedCrossRef
17.
go back to reference Cochrane RA, Valasiadou P, Wilson AR, Al-Ghazal SK, Macmillan RD. Cosmesis and satisfaction after breast-conserving surgery correlates with the percentage of breast volume excised. Br J Surg. 2003;90:1505–9.PubMedCrossRef Cochrane RA, Valasiadou P, Wilson AR, Al-Ghazal SK, Macmillan RD. Cosmesis and satisfaction after breast-conserving surgery correlates with the percentage of breast volume excised. Br J Surg. 2003;90:1505–9.PubMedCrossRef
18.
go back to reference Krishnan L, Stanton AL, Collins CA, Liston VE, Jewell WR. Form or function? Part 2. Objective cosmetic and functional correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy. Cancer. 2001;91:2282–7.PubMedCrossRef Krishnan L, Stanton AL, Collins CA, Liston VE, Jewell WR. Form or function? Part 2. Objective cosmetic and functional correlates of quality of life in women treated with breast-conserving surgical procedures and radiotherapy. Cancer. 2001;91:2282–7.PubMedCrossRef
19.
go back to reference Mann RM, Loo CE, Wobbes T, Bult P, Barentsz JO, Gilhuijs KG, et al., The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast. Breast Cancer Res Treat. 2010;119:415–22.PubMedCrossRef Mann RM, Loo CE, Wobbes T, Bult P, Barentsz JO, Gilhuijs KG, et al., The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast. Breast Cancer Res Treat. 2010;119:415–22.PubMedCrossRef
20.
go back to reference Pengel KE, Loo CE, Teertstra HJ, Muller SH, Wesseling J, Peterse JL, et al. The impact of preoperative MRI on breast-conserving surgery of invasive cancer: a comparative cohort study. Breast Cancer Res Treat. 2009;116:161–9.PubMedCrossRef Pengel KE, Loo CE, Teertstra HJ, Muller SH, Wesseling J, Peterse JL, et al. The impact of preoperative MRI on breast-conserving surgery of invasive cancer: a comparative cohort study. Breast Cancer Res Treat. 2009;116:161–9.PubMedCrossRef
21.
go back to reference Hussien M, Lioe TF, Finnegan J, Spence RA. Surgical treatment for invasive lobular carcinoma of the breast. Breast. 2003;12:23–35.PubMedCrossRef Hussien M, Lioe TF, Finnegan J, Spence RA. Surgical treatment for invasive lobular carcinoma of the breast. Breast. 2003;12:23–35.PubMedCrossRef
22.
go back to reference O’Sullivan MJ, Li T, Freedman G, Morrow M. The effect of multiple reexcisions on the risk of local recurrence after breast conserving surgery. Ann Surg Oncol. 2007;14:3133–40.PubMedCrossRef O’Sullivan MJ, Li T, Freedman G, Morrow M. The effect of multiple reexcisions on the risk of local recurrence after breast conserving surgery. Ann Surg Oncol. 2007;14:3133–40.PubMedCrossRef
23.
go back to reference van den Broek N, van der Sangen MJ, van de Poll-Franse LV, van Beek MW, Nieuwenhuijzen GA, Voogd AC. Margin status and the risk of local recurrence after breast-conserving treatment of lobular breast cancer. Breast Cancer Res Treat. 2007;105:63–8.PubMedCrossRef van den Broek N, van der Sangen MJ, van de Poll-Franse LV, van Beek MW, Nieuwenhuijzen GA, Voogd AC. Margin status and the risk of local recurrence after breast-conserving treatment of lobular breast cancer. Breast Cancer Res Treat. 2007;105:63–8.PubMedCrossRef
24.
go back to reference Morrow M, Keeney K, Scholtens D, Wei J, Steel J, Khan SA. Selecting patients for breast-conserving therapy: the importance of lobular histology. Cancer. 2006;106:2563–8.PubMedCrossRef Morrow M, Keeney K, Scholtens D, Wei J, Steel J, Khan SA. Selecting patients for breast-conserving therapy: the importance of lobular histology. Cancer. 2006;106:2563–8.PubMedCrossRef
25.
go back to reference Dillon MF, Hill AD, Fleming FJ, O’Doherty A, Quinn CM, McDermott EW, et al. Identifying patients at risk of compromised margins following breast conservation for lobular carcinoma. Am J Surg. 2006;191:201–5.PubMedCrossRef Dillon MF, Hill AD, Fleming FJ, O’Doherty A, Quinn CM, McDermott EW, et al. Identifying patients at risk of compromised margins following breast conservation for lobular carcinoma. Am J Surg. 2006;191:201–5.PubMedCrossRef
26.
go back to reference Liberman L, Morris EA, Kim CM, Kaplan JB, Abramson AF, Menell JH, et al. MR imaging findings in the contralateral breast of women with recently diagnosed breast cancer. AJR Am J Roentgenol. 2003;180:333–41.PubMed Liberman L, Morris EA, Kim CM, Kaplan JB, Abramson AF, Menell JH, et al. MR imaging findings in the contralateral breast of women with recently diagnosed breast cancer. AJR Am J Roentgenol. 2003;180:333–41.PubMed
27.
go back to reference Lehman CD, Gatsonis C, Kuhl CK, Hendrick RE, Pisano ED, Hanna L, et al. MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med. 2007;356:1295–303.PubMedCrossRef Lehman CD, Gatsonis C, Kuhl CK, Hendrick RE, Pisano ED, Hanna L, et al. MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer. N Engl J Med. 2007;356:1295–303.PubMedCrossRef
28.
go back to reference Yeatman TJ, Cantor AB, Smith TJ, Smith SK, Reintgen DS, Miller MS, et al. Tumor biology of infiltrating lobular carcinoma. Implications for management. Ann Surg. 1995;222:549–59; discussion 559–61.PubMed Yeatman TJ, Cantor AB, Smith TJ, Smith SK, Reintgen DS, Miller MS, et al. Tumor biology of infiltrating lobular carcinoma. Implications for management. Ann Surg. 1995;222:549–59; discussion 559–61.PubMed
Metadata
Title
Does a Supplementary Preoperative Breast MRI in Patients with Invasive Lobular Breast Cancer Change Primary and Secondary Surgical Interventions?
Authors
Joerg Heil, MD
Anne Bühler
Michael Golatta, MD
Joachim Rom, MD
Aba Harcos, MD
Anne Schipp, MD
Geraldine Rauch, PhD
Hans Junkermann, MD
Christof Sohn, MD
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 8/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-011-1565-y

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