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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 6/2011

01-06-2011 | Colorectal Cancer

Prognostic Value of Nuclear β-catenin Overexpression at Invasive Front in Colorectal Cancer for Synchronous Liver Metastasis

Authors: Lin Wang, MD, Hongxia Cheng, MD, Ying Liu, MD, Lei Wang, MD, Wenbin Yu, MD, Guangyong Zhang, MD, Bo Chen, MD, Zhiyong Yu, MD, Sanyuan Hu, MD

Published in: Annals of Surgical Oncology | Issue 6/2011

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Abstract

Background

β-catenin plays an important role in colorectal tumorigenesis. Relatively little is known about the relationship between β-catenin overexpression and liver metastasis. The purpose of this study was to investigate whether nuclear β-catenin overexpression in colorectal cancer is associated with synchronous liver metastasis.

Methods

The β-catenin expression in tumor tissue from 486 patients with colorectal cancer was examined by immunohistochemistry. The relationship between nuclear β-catenin expression in colorectal cancers and liver metastatic lesions and other clinicopathological characteristics was analyzed. Univariate analysis and logistic multivariate regression analysis were adopted to discriminate risk factors of liver metastasis.

Results

Nuclear β-catenin overexpression at the invasive front of the primary tumor in patients with liver metastasis is more evident than that in patients without liver metastasis (71.5% vs. 29.3%; P < 0.001). Nuclear β-catenin expression in primary tumors had a positive correlation with that in the matched metastatic lesions (r = 0.499, P < 0.001). Univariate and multivariate analyses indicated that overexpression of nuclear β-catenin at the invasive front in colorectal cancer correlated with liver metastasis.

Conclusions

Overexpression of nuclear β-catenin at the invasive front in colorectal cancer is strongly associated with liver metastasis and may be a promising predictor of liver metastasis.
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Metadata
Title
Prognostic Value of Nuclear β-catenin Overexpression at Invasive Front in Colorectal Cancer for Synchronous Liver Metastasis
Authors
Lin Wang, MD
Hongxia Cheng, MD
Ying Liu, MD
Lei Wang, MD
Wenbin Yu, MD
Guangyong Zhang, MD
Bo Chen, MD
Zhiyong Yu, MD
Sanyuan Hu, MD
Publication date
01-06-2011
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 6/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-1519-9

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