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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 5/2011

Open Access 01-05-2011 | Head and Neck Oncology

Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma

Authors: Mu-Kuan Chen, MD, MS, PhD, Chih-Ming Chen, MD, Ming-Che Lee, MS, Li-Sheng Chen, PhD, Hui-Chuan Chen, PhD

Published in: Annals of Surgical Oncology | Issue 5/2011

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Abstract

Background

We evaluated the heterogeneity of primary tumor volume (PTV) within tumors of the same pT4a-staged tongue carcinoma and to elucidate the effects of PTV on treatment outcomes in patients with pT4a-staged tongue carcinoma.

Methods

Fifty-eight patients with newly diagnosed pT4a-staged tongue carcinoma who received surgery were enrolled onto this study. Magnetic resonance imaging–derived PTV was measured by the summation-of-area technique.

Results

The mean PTV was 24.55 ml, with a range of 5.32 to 119.64 ml. The receiver operating characteristic curve was applied, and the optimal cutoff volume was 23 ml. Large PTV was associated with a significantly poor disease-specific survival (P = 0.010) by the log rank test. The Cox regression model also revealed that large PTV (P = 0.026) and positive lymphatic node metastasis (P = 0.004) were statistically significant in the prognosis of T4a-staged tongue carcinoma.

Conclusions

A substantial variation of PTV was present within the same pT4a-staged tongue carcinoma, and PTV represented an important prognostic factor. In the light of these findings, we suggest that taking the PTV into account in pT4a-staged tongue carcinoma would better refine the newest revised T classification, and the treatment strategies may be different.
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Metadata
Title
Primary Tumor Volume Is an Independent Predictor of Outcome Within pT4a-Staged Tongue Carcinoma
Authors
Mu-Kuan Chen, MD, MS, PhD
Chih-Ming Chen, MD
Ming-Che Lee, MS
Li-Sheng Chen, PhD
Hui-Chuan Chen, PhD
Publication date
01-05-2011
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 5/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-1489-y

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