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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 7/2011

Open Access 01-07-2011 | Breast Oncology

Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer

Authors: Hee Jeong Kim, MD, PhD, Yu Mi Lee, MD, Beon Seok Ko, MD, Jong Won Lee, MD, Jong Han Yu, MD, Byung Ho Son, MD, PhD, Gyung-Yub Gong, MD, PhD, Sung Bae Kim, MD, PhD, Sei Hyun Ahn, MD, PhD

Published in: Annals of Surgical Oncology | Issue 7/2011

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Abstract

Purpose

Vitamin D deficiency may be an indicator of poor prognosis in patients with breast cancer before surgery. We investigated the association between serum vitamin D concentration and breast cancer prognosis according to intrinsic cancer subtypes.

Methods

From June to December 2006, serum 25-OHD was measured in 310 Korean women with breast cancer who were treated at the Asan Medical Center, Korea. Clinicopathologic data were examined to determine the prognostic effects of serum 25-OHD. Expression of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (Her2) were measured using tissue microarrays. Patients were classified with luminal A, luminal B, Her2-enriched, or basal-like subtypes of breast cancer.

Results

Mean patient age was 48.7 years, and mean serum 25-OHD concentration was 31.4 ± 16.1 ng/ml. The 25-OHD levels were deficient (< 20 ng/ml) in 75 patients (24.2%), insufficient (20–29 ng/ml) in 95 (30.6%), and sufficient (30–150 ng/ml) in 140 (45.2%). Women with deficient 25-OHD levels were at increased risk of recurrence compared with those with sufficient vitamin D levels (P = 0.002). The 25-OHD concentration was inversely associated with prognosis of patients with cancer of the luminal A (P = 0.012) and luminal B subtypes (P = 0.023), but not with the prognosis of patients with Her2/neu-enriched (P = 0.245) or triple-negative (P = 0.879) cancer subtypes. This association remained valid after adjustment for age, tumor size, nodal status, and estrogen receptor status (hazards ratio = 3.97; 95% confidence interval = 1.77–9.61).

Conclusions

Vitamin D deficiency may be associated with poor outcomes in patients with luminal-type breast cancer.
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Metadata
Title
Vitamin D Deficiency is Correlated with Poor Outcomes in Patients with Luminal-type Breast Cancer
Authors
Hee Jeong Kim, MD, PhD
Yu Mi Lee, MD
Beon Seok Ko, MD
Jong Won Lee, MD
Jong Han Yu, MD
Byung Ho Son, MD, PhD
Gyung-Yub Gong, MD, PhD
Sung Bae Kim, MD, PhD
Sei Hyun Ahn, MD, PhD
Publication date
01-07-2011
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 7/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-1465-6

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