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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 2/2011

01-02-2011 | Gastrointestinal Oncology

Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer

Authors: Nam P. Nguyen, MD, Misty Ceizyk, CMD, Fabio Almeida, MD, Alexander Chi, MD, Michael Betz, MD, Homayoun Modarresifar, MD, Thomas Sroka, MD, Deirdre Cohen, MD, Siyoung Jang, PhD, Dave Abraham, CMD, Michelle Stevie, BS, Lexie Smith-Raymond, CMD, Shane Krafft, BS, Vincent Vinh-Hung, MD

Published in: Annals of Surgical Oncology | Issue 2/2011

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Abstract

Background

Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer.

Methods

A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted.

Results

Nineteen patients (median age, 69 years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group—patients who had pCR and those who did not have pCR—was 14, 17, and 15 months, respectively.

Conclusions

Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials.
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Metadata
Title
Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer
Authors
Nam P. Nguyen, MD
Misty Ceizyk, CMD
Fabio Almeida, MD
Alexander Chi, MD
Michael Betz, MD
Homayoun Modarresifar, MD
Thomas Sroka, MD
Deirdre Cohen, MD
Siyoung Jang, PhD
Dave Abraham, CMD
Michelle Stevie, BS
Lexie Smith-Raymond, CMD
Shane Krafft, BS
Vincent Vinh-Hung, MD
Publication date
01-02-2011
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 2/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-1329-0

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