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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2011

Open Access 01-01-2011 | Head and Neck Oncology

Salvage Surgery for Neck Residue or Recurrence of Nasopharyngeal Carcinoma: A 10-Year Experience

Authors: Ling Zhang, MD, Yong-xue Zhu, MD, Yu Wang, MD, Cai-ping Huang, MD, Yi Wu, MD, Qing-hai Ji, MD

Published in: Annals of Surgical Oncology | Issue 1/2011

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Abstract

Background

To assess the outcome of and determine prognostic factors for neck residue or recurrence of nasopharyngeal carcinoma (NPC) in patients treated with a salvage neck dissection.

Materials and Methods

Over a 10-year period (from January 1998 through December 2007) in a tertiary hospital, we systematically reviewed the clinical charts of 355 patients with NPC who were diagnosed with neck residue or recurrence of nasopharyngeal carcinoma, after radical definitive radiotherapy with or without chemotherapy.

Results

The group with recurrent nodal disease consisted of 285 patients (80.3%), while the group with residual nodal disease included 70 patients (19.7%). There were no patients died of the surgery complications. Overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) were 54.11, 35.01, and 55.59%, respectively, at 3-year, and 26.03, 22.65, and 27.84%, respectively, at 5-year. The local control rate in the neck was 70.92% at 3 years and 60.98% at 5 years. For all the 3 survival outcomes (OS, DFS, and DSS) and the local control rate of disease in the neck, there were significant differences between the “residue group” and “recurrence group.”

Conclusions

Radical neck dissection is proven to be safe and effective in the treatment of the neck failure. Our study has demonstrated that it may be possible to choose the selective lymph node dissection for patients of the residue group.
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Metadata
Title
Salvage Surgery for Neck Residue or Recurrence of Nasopharyngeal Carcinoma: A 10-Year Experience
Authors
Ling Zhang, MD
Yong-xue Zhu, MD
Yu Wang, MD
Cai-ping Huang, MD
Yi Wu, MD
Qing-hai Ji, MD
Publication date
01-01-2011
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 1/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-010-1292-9

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