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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 5/2010

01-05-2010 | Colorectal Cancer

High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer

Authors: Dake Chu, MD, Yunming Li, MD, Weizhong Wang, MM, Qingchuan Zhao, MD, Jipeng Li, MD, Yuanyuan Lu, MD, Mengbin Li, MD, Guanglong Dong, MD, Hongwei Zhang, MD, Huahong Xie, MD, Gang Ji, MD

Published in: Annals of Surgical Oncology | Issue 5/2010

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Abstract

Background

Notch1 regulates cell proliferation, development, and apoptosis. Aberrant expression of Notch1 has been discovered in many types of tumors. We examined Notch1 expression in colorectal cancer to assess its role as a prognostic indicator.

Methods

Notch1 protein expression was examined by immunohistochemistry in 223 surgically resected specimens of colorectal cancer and adjacent tissues. The relationship between various clinicopathological features and overall patient survival rate was analyzed. The association of Notch1 expression with the colorectal cancer survival rate was assessed by Kaplan–Meier and Cox proportional-hazards regression.

Results

Significantly high Notch1 expression was found in colorectal cancer cells compared with that of normal colorectal epithelial cells. Notch1 was positively correlated with depth of invasion (P = 0.005), lymph node metastases (P = 0.03), and tumor–node–metastasis (TNM) stage (P < 0.001). Consistently, the overall survival rate was significantly lower for patients with Notch1-positive than those with Notch1-negative tumors. However, no correlation between Notch1 expression and patient age, sex or tumor location was found.

Conclusion

Notch1 might serve as a novel prognostic marker that is independent of, and additive to, the TNM staging system.
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Metadata
Title
High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer
Authors
Dake Chu, MD
Yunming Li, MD
Weizhong Wang, MM
Qingchuan Zhao, MD
Jipeng Li, MD
Yuanyuan Lu, MD
Mengbin Li, MD
Guanglong Dong, MD
Hongwei Zhang, MD
Huahong Xie, MD
Gang Ji, MD
Publication date
01-05-2010
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 5/2010
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0893-7

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