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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 9/2009

01-09-2009 | Radiation Oncology

Challenges in Personalizing Decisions on Whole, Partial or No Breast Irradiation and Extent of Surgery for Early Breast Cancer

Authors: Pericles Tsekeris, MD, Antonio Capizello, MD, Dimitrios Roukos, MD

Published in: Annals of Surgical Oncology | Issue 9/2009

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Excerpt

Breast-conserving surgery (BCS), and adjuvant radiotherapy and systemic treatment is the standard of care for early breast cancer. Whole breast irradiation (WBI) of 50 Gy and systemic treatment consisting of empirical chemotherapeutic and targeted agents according to hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status is used in current clinical practice. …
Literature
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Roukos DH. Genetics and genome-wide association studies: surgery-guided algorithm and promise for future breast cancer personalized surgery. Expert Rev Mol Diagn. 2008;8(5):587–97.PubMedCrossRef
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Khan AJ, Vicini F, Beitsch P, Haffty B, Quiet C, Keleher A, et al. Local control, toxicity, and cosmesis in women younger than 50 enrolled onto the American Society of Breast Surgeons MammoSite Radiation Therapy System Registry Trial. Ann Surg Oncol. 2009;16(6):1612–8.PubMedCrossRef
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Roukos DH. Mea Culpa with cancer-targeted therapy: new thinking and new agents design for novel, causal networks-based, personalized biomedicine. Expert Rev Mol Diagn. 2009;9(3):217–21.PubMedCrossRef
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Roukos DH. Personalized cancer diagnostics and therapeutics. Expert Rev Mol Diagn. 2009;9(3):227–9.PubMedCrossRef
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Roukos DH. Twenty-one-gene assay: challenges and promises in translating personal genomics and whole-genome scans into personalized treatment of breast cancer. J Clin Oncol. 2009;27(8):1337–8.PubMedCrossRef
Metadata
Title
Challenges in Personalizing Decisions on Whole, Partial or No Breast Irradiation and Extent of Surgery for Early Breast Cancer
Authors
Pericles Tsekeris, MD
Antonio Capizello, MD
Dimitrios Roukos, MD
Publication date
01-09-2009
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 9/2009
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0556-8

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