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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2009

Open Access 01-04-2009 | Hepatobiliary and Pancreatic Tumors

Differentiating Early and Late Recurrences After Resection of HCC in Cirrhotic Patients: Implications on Surveillance, Prevention, and Treatment Strategies

Author: Ronnie T. P. Poon, MBBS, MS, PhD, FRCS (Ed), FACS

Published in: Annals of Surgical Oncology | Issue 4/2009

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Excerpt

Hepatocellular carcinoma (HCC) is one of the most common human malignancies. The majority of HCCs occur in a background of cirrhosis related to hepatitis B virus, hepatitis C virus, or alcoholism. The presence of cirrhosis has significant impact on the management of the cancer. The impairment of liver function as a result of cirrhosis restricts the treatment options, and cirrhosis is also known to predispose to multicentric hepatocarcinogenesis and increase the risk of recurrence after resection of HCC.1 The advent of liver transplantation and radiofrequency ablation have provided better chances of curative treatment for patients with small HCC detected by screening in recent years; however, hepatic resection remains the mainstay of curative treatment for HCC associated with Child-Pugh class A cirrhosis.2 While the perioperative safety and long-term survival of liver resection in cirrhotic liver have improved in recent years, the rate of postoperative recurrence of HCC remains high.3 …
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Metadata
Title
Differentiating Early and Late Recurrences After Resection of HCC in Cirrhotic Patients: Implications on Surveillance, Prevention, and Treatment Strategies
Author
Ronnie T. P. Poon, MBBS, MS, PhD, FRCS (Ed), FACS
Publication date
01-04-2009
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 4/2009
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-009-0330-y

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