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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 12/2008

01-12-2008 | Gastrointestinal Oncology

Preoperative Serum Carcinoembryonic Antigen Level as a Predictive Factor of Recurrence After Curative Resection of Colorectal Cancer

Authors: Ryo Takagawa, MD, Syoichi Fujii, MD, PhD, Mitsuyoshi Ohta, MD, PhD, Yasuhiko Nagano, MD, PhD, Chikara Kunisaki, MD, PhD, Shigeru Yamagishi, MD, PhD, Shunichi Osada, MD, PhD, Yasushi Ichikawa, MD, PhD, Hiroshi Shimada, MD, PhD

Published in: Annals of Surgical Oncology | Issue 12/2008

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Abstract

Background

We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colorectal cancer (CRC).

Patients and Methods

The study group comprised 638 patients. The optimal cutoff value for the preoperative serum CEA level was determined. Predictive factors of recurrence were evaluated using multivariate analyses. The relapse-free time was investigated according to the CEA level.

Results

All patients underwent potentially curative resection for CRC without distant metastasis, classified as stage I, II, or III. The optimal cutoff value for preoperative serum CEA level was 10 ng/ml. Elevated preoperative serum CEA level was observed in 92 patients. Multivariate analysis identified tumor–node–metastasis (TNM) stage and preoperative serum CEA level as independent predictive factors of recurrence. The relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml significantly differed in patients with stage II and III. However, there was no significant difference in relapse-free survival between CEA levels >10 ng/ml and <10 ng/ml in patients with stage I.

Conclusion

Preoperative serum CEA is a reliable predictive factor of recurrence after curative surgery in CRC patients and a useful indicator of the optimal treatment after resection, particularly for cases classified as stage II or stage III.
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Metadata
Title
Preoperative Serum Carcinoembryonic Antigen Level as a Predictive Factor of Recurrence After Curative Resection of Colorectal Cancer
Authors
Ryo Takagawa, MD
Syoichi Fujii, MD, PhD
Mitsuyoshi Ohta, MD, PhD
Yasuhiko Nagano, MD, PhD
Chikara Kunisaki, MD, PhD
Shigeru Yamagishi, MD, PhD
Shunichi Osada, MD, PhD
Yasushi Ichikawa, MD, PhD
Hiroshi Shimada, MD, PhD
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 12/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-008-0168-8

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