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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 10/2008

01-10-2008 | Laboratory Research

Ablation of High Intensity Focused Ultrasound Combined with SonoVue on Rabbit VX2 Liver Tumors: Assessment with Conventional Gray-Scale US, Conventional Color/Power Doppler US, Contrast-Enhanced Color Doppler US, and Contrast-Enhanced Pulse-Inversion Harmonic US

Authors: Wen Luo, MD, Xiaodong Zhou, MD, Guangbin He, MD, Qiuyang Li, MD, Xiaoying Zheng, MD, Zhiyong Fan, MD, Qing Liu, MD, Ming Yu, MD, Zenghui Han, MD, Jun Zhang, MD, Yunqiu Qian, MD

Published in: Annals of Surgical Oncology | Issue 10/2008

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Abstract

Background

We investigated effects of high intensity focused ultrasound (HIFU) combined with contrast agent SonoVue on rabbit VX2 liver tumors by using conventional gray-scale ultrasonography (US), color/power Doppler (CD/PD) US, contrast-enhanced color Doppler (CE CD) US, and contrast-enhanced pulse-inversion harmonic (CE PIH) US.

Methods

Fourteen days after implantation of VX2 tumors in livers of 50 rabbits, animals were randomly separated into two groups. Based on principles of HIFU, the volume of the tumor was divided into several parallel “planes” to be ablated. Before ablation on each “plane,” 0.2 mL SonoVue was injected in bolus via ear veins of rabbits in group II and normal saline solution was administrated in group I. Conventional gray-scale US, CD US, PD US, CE CD US, and CE PIH US were performed before and after ablation.

Results

Twenty-three surviving rabbits in each group underwent HIFU ablation. Conventional gray-scale US showed ablated areas diffusely hyperechoic. On CE PIH US, coagulated areas presented perfusion defect. Both conventional gray-scale US and CE PIH US showed the ablated volume in group II was larger than that in group I. CD US and PD US demonstrated residual vessels in periphery ablated areas in group I, but no residual vessels in group II. CE CD US and CE PIH US depicted less residual vessels in periphery ablated areas in group II than that in group I.

Conclusion

By enlarging ablated volume of tissue and reducing residual vessels, effects of HIFU ablation on rabbit VX2 liver tumors were enhanced by contrast agent SonoVue.
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Metadata
Title
Ablation of High Intensity Focused Ultrasound Combined with SonoVue on Rabbit VX2 Liver Tumors: Assessment with Conventional Gray-Scale US, Conventional Color/Power Doppler US, Contrast-Enhanced Color Doppler US, and Contrast-Enhanced Pulse-Inversion Harmonic US
Authors
Wen Luo, MD
Xiaodong Zhou, MD
Guangbin He, MD
Qiuyang Li, MD
Xiaoying Zheng, MD
Zhiyong Fan, MD
Qing Liu, MD
Ming Yu, MD
Zenghui Han, MD
Jun Zhang, MD
Yunqiu Qian, MD
Publication date
01-10-2008
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 10/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-008-0032-x

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