Skip to main content
Top
Published in: Annals of Surgical Oncology 5/2008

Open Access 01-05-2008 | Breast Oncology

Positive Margins: The Challenge Continues for Breast Surgeons

Author: Lisa Jacobs

Published in: Annals of Surgical Oncology | Issue 5/2008

Login to get access

Excerpt

As breast cancer treatment has progressed to offering breast preservation to the majority of patients, a new challenge has arisen. That challenge is adequate margins on the partial mastectomy specimen. The literature reports positive margins in 20–70% of patients, resulting in additional surgery. While the consequences of that additional surgery probably do not affect survival from breast cancer, they do potentially have an affect on cosmesis, wound infection risk, and the confidence that the patient has with the surgeon wondering “why didn’t you get it all?” …
Literature
1.
go back to reference Waljee J, Hu E, Newman L, Alderman A. Predictors of re-excision among women undergoing breast conserving surgery for cancer. Ann Surg Oncol (in press) Waljee J, Hu E, Newman L, Alderman A. Predictors of re-excision among women undergoing breast conserving surgery for cancer. Ann Surg Oncol (in press)
2.
go back to reference Smitt MC, Horst K. Association of clinical and pathologic variables with lumpectomy surgical margin status after preoperative diagnosis or excisional biopsy of invasive breast cancer. Ann Surg Oncol 2007; 14:1040–4PubMedCrossRef Smitt MC, Horst K. Association of clinical and pathologic variables with lumpectomy surgical margin status after preoperative diagnosis or excisional biopsy of invasive breast cancer. Ann Surg Oncol 2007; 14:1040–4PubMedCrossRef
3.
go back to reference Chagpar AB, Martin RCG, Hagendoorn LJ, et al. Lumpectomy margins are affected by tumor size and histologic subtype but not by biopsy technique. Am J Surg 2004; 188:399–402PubMedCrossRef Chagpar AB, Martin RCG, Hagendoorn LJ, et al. Lumpectomy margins are affected by tumor size and histologic subtype but not by biopsy technique. Am J Surg 2004; 188:399–402PubMedCrossRef
4.
go back to reference Muttalib M, Tai CC, Briant-Evans T, et al. Intra-operative assessment of excision margins using breast imprint and scrape cytology. Breast 2005; 14:42–50PubMedCrossRef Muttalib M, Tai CC, Briant-Evans T, et al. Intra-operative assessment of excision margins using breast imprint and scrape cytology. Breast 2005; 14:42–50PubMedCrossRef
5.
go back to reference Balch GC, Mithani SK, Simpson JF, et al. Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy. Am Surg 2005; 71:22–7PubMed Balch GC, Mithani SK, Simpson JF, et al. Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy. Am Surg 2005; 71:22–7PubMed
6.
go back to reference Cabioglu N, Hunt KK, Sahin AA, et al. Role for intraoperative margin assessment in patients undergoing breast-conserving surgery. Ann Surg Oncol 2007; 14:1458–71PubMedCrossRef Cabioglu N, Hunt KK, Sahin AA, et al. Role for intraoperative margin assessment in patients undergoing breast-conserving surgery. Ann Surg Oncol 2007; 14:1458–71PubMedCrossRef
7.
go back to reference Tafra L, Fine R, Whitworth P, et al. Prospective randomized study comparing cryo-assisted and needle-wire localization of ultrasound-visible breast tumors. Am J Surg 2006; 192:462–70PubMedCrossRef Tafra L, Fine R, Whitworth P, et al. Prospective randomized study comparing cryo-assisted and needle-wire localization of ultrasound-visible breast tumors. Am J Surg 2006; 192:462–70PubMedCrossRef
8.
go back to reference Nadeem R, Chagla LS, Harris O, et al. Occult breast lesions: A comparison between radioguided occult lesion localization (ROLL) vs. wire-guided lumpectomy (WGL). Breast 2005; 14:283–9PubMedCrossRef Nadeem R, Chagla LS, Harris O, et al. Occult breast lesions: A comparison between radioguided occult lesion localization (ROLL) vs. wire-guided lumpectomy (WGL). Breast 2005; 14:283–9PubMedCrossRef
9.
go back to reference Buzdar AU, Ibrahim NK, Francis D, et al. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2–positive operable breast cancer. J Clin Oncol 2005; 23:3676–85PubMedCrossRef Buzdar AU, Ibrahim NK, Francis D, et al. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2–positive operable breast cancer. J Clin Oncol 2005; 23:3676–85PubMedCrossRef
Metadata
Title
Positive Margins: The Challenge Continues for Breast Surgeons
Author
Lisa Jacobs
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 5/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-007-9766-0

Other articles of this Issue 5/2008

Annals of Surgical Oncology 5/2008 Go to the issue