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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 2/2008

01-02-2008 | Gastrointestinal Oncology

A Novel Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Gastric Cancer Susceptibility in Taiwan

Authors: Chang-Fang Chiu, MD, PhD, Chung-Hsing Wang, MD, Cheng-Li Wang, MD, Cheng-Chieh Lin, MD, PhD, Nan-Yung Hsu, MD, Jing-Ru Weng, PhD, Da-Tian Bau, PhD

Published in: Annals of Surgical Oncology | Issue 2/2008

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Abstract

Background

The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. We investigate some novel and important polymorphic variants of XRCC4, at codon 247 (rs3734091), G-1394T (rs6869366), intron 3 (rs28360071), and intron 7 (rs28360317), of their associated with gastric cancer susceptibility.

Materials and Methods

In this hospital-based case-control study, the association of XRCC4 polymorphisms with gastric cancer risk in a Taiwanese population was investigated. In total, 121 patients with gastric cancer and 121 age-matched healthy controls recruited were genotyped investigating these polymorphisms’ association with gastric cancer susceptibility.

Results

We found a significant difference in the frequency of the XRCC4 G-1394T genotype, but not others, between the gastric cancer and control groups. Those who had G/T or G/G at XRCC4 G-1394T showed a 3.79-fold (95% confidence interval = 1.47–9.82) increased risk of gastric cancer compared to those with T/T. As for XRCC4 codon 247, intron 3, or intron 7, there was no difference in distribution between the gastric cancer and control groups.

Conclusions

Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.
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Metadata
Title
A Novel Single Nucleotide Polymorphism in XRCC4 Gene is Associated with Gastric Cancer Susceptibility in Taiwan
Authors
Chang-Fang Chiu, MD, PhD
Chung-Hsing Wang, MD
Cheng-Li Wang, MD
Cheng-Chieh Lin, MD, PhD
Nan-Yung Hsu, MD
Jing-Ru Weng, PhD
Da-Tian Bau, PhD
Publication date
01-02-2008
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 2/2008
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-007-9674-3

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