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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 5/2009

01-05-2009 | Thoracic Oncology

h-prune Is an Independent Prognostic Marker for Survival in Esophageal Squamous Cell Carcinoma

Authors: Tsuyoshi Noguchi, MD, PhD, Naohide Oue, MD, PhD, Shinsuke Wada, MD, PhD, Kazuhiro Sentani, MD, Naoya Sakamoto, MD, Akira Kikuchi, MD, PhD, Wataru Yasui, MD, PhD

Published in: Annals of Surgical Oncology | Issue 5/2009

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Abstract

Background

The human homologue of Drosophila prune (PRUNE, which encodes h-prune) protein interacts with glycogen synthase kinase 3 and promotes cell motility. The aim of our study was to investigate the impact of immunohistochemically detected h-prune expression on the survival of patients with esophageal squamous cell carcinoma (ESCC).

Methods

Immunohistochemical staining of h-prune was performed for 205 surgically resected specimens of ESCC.

Results

In total, 43 (21%) of 205 ESCC cases were positive for h-prune. h-prune-positive ESCC cases showed a more-advanced T stage (P < 0.0001), N stage (P < 0.0001), and tumor stage (P < 0.0001) than h-prune-negative ESCC cases. In the group of 116 stage II and III ESCC cases, recurrence of ESCC was frequently found in h-prune-positive cases. In patients with lung recurrence, the tumors were more likely to be h-prune positive than h-prune negative. Univariate analysis revealed that T stage (P < 0.0001), N stage (P < 0.0001), tumor stage (P < 0.0001), and h-prune staining (P < 0.0001) were significant prognostic factors for survival. Multivariate analysis indicated that N stage (P = 0.0182) and h-prune staining (P < 0.0001) were independent predictors for survival.

Conclusions

These results indicate that immunostaining of h-prune is useful to identify patients at high risk for recurrence or poor prognosis associated with ESCC.
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Metadata
Title
h-prune Is an Independent Prognostic Marker for Survival in Esophageal Squamous Cell Carcinoma
Authors
Tsuyoshi Noguchi, MD, PhD
Naohide Oue, MD, PhD
Shinsuke Wada, MD, PhD
Kazuhiro Sentani, MD
Naoya Sakamoto, MD
Akira Kikuchi, MD, PhD
Wataru Yasui, MD, PhD
Publication date
01-05-2009
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 5/2009
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-007-9585-3

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