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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2007

01-03-2007

Clinical Characteristics and Surgical Outcome in Hepatocellular Carcinoma without Hepatitis B Virus Surface Antigen or Hepatitis C Virus Antibody

Authors: Kuniya Tanaka, MD, PhD, Hiroshi Shimada, MD, PhD, Kenichi Matsuo, MD, Yasuhiko Nagano, MD, Itaru Endo, MD, PhD, Shinji Togo, MD, PhD

Published in: Annals of Surgical Oncology | Issue 3/2007

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Abstract

Objective

We investigated clinical characteristics and surgical outcome of hepatocellular carcinoma in association with hepatitis viral status.

Summary Background Data

No consensus exists concerning differences in surgical outcome in patients with hepatocellular carcinoma according to viral hepatitis status, especially those negative for hepatitis B virus surface antigen and antibody to hepatitis C virus.

Methods

Clinicopathologic data were available for 39 hepatectomy patients with hepatocellular carcinoma who were negative for hepatitis B virus surface antigen and hepatitis C virus antibody. Clinical characteristics and surgical outcome were analyzed retrospectively and compared to those patients with positive hepatitis viral markers.

Results

Patients negative for viral hepatitis markers were more likely to have large, advanced-stages tumors with relatively well-preserved liver function and had a lower incidence of intrahepatic recurrences (P = 0.009). The intrahepatic recurrence rate reached a plateau at approximately 3 years after resection in patients with negative viral markers, while it continued to increase steadily in patients positive for viral hepatitis markers. By multivariable analysis, the absence of viral hepatitis markers predicted a decreased rate of intrahepatic recurrence (relative risk, 0.222; P = 0.001).

Conclusions

Adequate surgical resection in hepatocellular carcinoma patients negative for viral markers offers a good survival benefit, regardless of the etiology of the hepatocellular carcinoma.
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Metadata
Title
Clinical Characteristics and Surgical Outcome in Hepatocellular Carcinoma without Hepatitis B Virus Surface Antigen or Hepatitis C Virus Antibody
Authors
Kuniya Tanaka, MD, PhD
Hiroshi Shimada, MD, PhD
Kenichi Matsuo, MD
Yasuhiko Nagano, MD
Itaru Endo, MD, PhD
Shinji Togo, MD, PhD
Publication date
01-03-2007
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 3/2007
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-006-9299-y

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