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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 5/2005

01-05-2005 | Editorial

Epigenetics and Biliary Cancer: Promise and Pitfalls

Author: Edward E. Whang, MD

Published in: Annals of Surgical Oncology | Issue 5/2005

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Excerpt

Epigenetic inheritance is the transmission during cell division of information that controls gene expression through templates that are independent of the DNA sequence itself. Of the mechanisms known to mediate epigenetic inheritance, DNA methylation is the best characterized. Dense methylation of promoter regions is associated with a compacted chromatin structure and accompanying transcriptional silencing of associated genes. First documented in the early 1990s, epigenetic silencing of tumor-suppressor genes by promoter hypermethylation is now known to be prevalent in a wide range of human malignancies.1 …
Literature
1.
2.
Koga Y, Kitajima Y, Miyoshi A, et al. Tumor progression through epigenetic gene silencing of MGMT in human biliary tract cancers. Ann Surg Oncol (in press)
3.
Kohya, N, Miyazaki, K, Matsukura, S,  et al. 2002Deficient expression of O6-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and MSHS is related to poor prognosis in human biliary tract carcinomaAnn Surg Oncol93719CrossRefPubMed
4.
Yang, B, House, MG, Guo, M, Herman, JG, Clark, DP 2004Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinomaMod Pathol1841220CrossRef
Metadata
Title
Epigenetics and Biliary Cancer: Promise and Pitfalls
Author
Edward E. Whang, MD
Publication date
01-05-2005
Publisher
Springer-Verlag
Published in
Annals of Surgical Oncology / Issue 5/2005
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/ASO.2005.02.909

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