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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2023

27-09-2023 | Metastasis | ASO Author Reflections

ASO Author Reflections: Microsatellite Unstable Colon Cancer, Lymph Node Metastases, and Risk of Recurrence

Authors: Asama Khan, MD, Lynn Hakki, MD, Martin R. Weiser, MD

Published in: Annals of Surgical Oncology | Issue 13/2023

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Excerpt

In the United States, colorectal cancer is the third most common cancer.1 The majority of colon cancers arise via the adenoma-to-carcinoma pathway. Historically, staging and treatment algorithms have been modeled with this in mind. However, approximately 15% of colon cancer cases arise via microsatellite instability (MSI) as a result of loss of function of a DNA mismatch repair protein.2 In contrast to microsatellite stable (MSS) disease, predictors of lymph node metastases and association with recurrence are not well defined for MSI colon cancer.3 Understanding how MSI tumors behave is vital for updating treatment algorithms appropriately. …
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Metadata
Title
ASO Author Reflections: Microsatellite Unstable Colon Cancer, Lymph Node Metastases, and Risk of Recurrence
Authors
Asama Khan, MD
Lynn Hakki, MD
Martin R. Weiser, MD
Publication date
27-09-2023
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-023-14359-6

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