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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2023

10-08-2023 | Gastric Cancer | ASO Author Reflections

ASO Author Reflections: Effects of TRPV2 on the Expression of PD-L1 and Its Ability to Bind to PD-1 in Gastric Cancer

Authors: Atsushi Shiozaki, MD, PhD, Tomoyuki Fukami, MD, PhD, Eigo Otsuji, MD, PhD

Published in: Annals of Surgical Oncology | Issue 13/2023

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Excerpt

Ion channels/transporters were recently shown to be crucially involved in a number of the fundamental functions of cancer cells, and a cellular physiologic approach has potential as a novel strategy in specific cancer treatments. In gastric cancer (GC), the authors previously investigated the expression and functions of Ca2+ channels, including transient receptor potential vanilloid 2 (TRPV2),1 and Cl– channels such as anoctamins (ANOs).2 …
Literature
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2.
Katsurahara K, Shiozaki A, Kosuga T, et al. ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer. Cancer Sci. 2021;112:1026–37.CrossRefPubMedPubMedCentral
3.
4.
Shiozaki A, Kudou M, Ichikawa D, et al. Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor. J Gastroenterol. 2018;53:197–207.CrossRefPubMed
5.
Shiozaki A, Kudou M, Fujiwara H, et al. Clinical safety and efficacy of neoadjuvant combination chemotherapy of tranilast in advanced esophageal squamous cell carcinoma: phase I/II study (TNAC). Medicine (Baltimore). 2020;99:e23633.CrossRefPubMed
Metadata
Title
ASO Author Reflections: Effects of TRPV2 on the Expression of PD-L1 and Its Ability to Bind to PD-1 in Gastric Cancer
Authors
Atsushi Shiozaki, MD, PhD
Tomoyuki Fukami, MD, PhD
Eigo Otsuji, MD, PhD
Publication date
10-08-2023
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-023-14121-y

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