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28-08-2023 | Translational Research

Exploring the Relationship: Low-Grade Appendiceal Mucinous Neoplasms (LAMN) and Mucinous Adenocarcinoma as Phases of the Same Disease Spectrum

Authors: Lance D. Miller, PhD, Konstantinos I. Votanopoulos, MD, PhD

Published in: Annals of Surgical Oncology | Issue 12/2023

Excerpt

Interpreting the genetic information in appendiceal cancer poses several challenges due to limited availability of data, presence of tumor heterogeneity, a lack of standardized testing methods, uncertainty regarding the clinical relevance of driver and passenger mutations, and limited integration of genetic information with clinical data. …

Ang CSP, Shen JP, Hardy-Abeloos CJ, Huang JK, Ross JS, Miller VA, et al. Genomic landscape of appendiceal neoplasms. JCO Precis Oncol. 2018;2:1–18. https://doi.org/10.1200/PO.17.00302.CrossRef

Levine EA, Blazer DG III, Kim MK, Shen P, Stewart JH IV, Guy C, et al. Gene expression profiling of peritoneal metastases from appendiceal and colon cancer demonstrates unique biologic signatures and predicts patient outcomes. J Am Coll Surg. 2012;214:599–606. https://doi.org/10.1016/j.jamcollsurg.2011.12.028.CrossRefPubMedPubMedCentral

Mangieri CW, Valenzuela CD, Erali RA, Votanopoulos KI, Shen P, Levine EA, et al. Incidence, risk factors, and outcomes from conversion of low-grade to high-grade appendiceal neoplasms for patients undergoing multiple cytoreductive surgeries with hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2022;29:205–11. https://doi.org/10.1245/s10434-021-10660-4.CrossRefPubMed

Votanopoulos KI, Mazzocchi A, Sivakumar H, Forsythe S, Aleman J, Levine EA, et al. Appendiceal cancer patient-specific tumor organoid model for predicting chemotherapy efficacy prior to initiation of treatment: a feasibility study. Ann Surg Oncol. 2019;26:139–47. https://doi.org/10.1245/s10434-018-7008-2.CrossRefPubMed

Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, et al. Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms. Br J Cancer. 2013;108:951–8. https://doi.org/10.1038/bjc.2013.47.CrossRefPubMedPubMedCentral

Foote MB, Walch H, Chatila W, Vakiani E, Chandler C, Steinruecke F, et al. Molecular classification of appendiceal adenocarcinoma. J Clin Oncol. 2023;41:1553–64. https://doi.org/10.1200/JCO.22.01392.CrossRefPubMed

Stadler ZK, Maio A, Chakravarty D, Kemel Y, Sheehan M, Salo-Mullen E, et al. Therapeutic implications of germline testing in patients with advanced cancers. J Clin Oncol. 2021;39:2698–709. https://doi.org/10.1200/JCO.20.03661.CrossRefPubMedPubMedCentral

Holowatyj AN, Washington MK, Tavtigian SV, Eng C, Horton C. Inherited cancer susceptibility gene sequence variations among patients with appendix cancer. JAMA Oncol. 2022;9:95–101. https://doi.org/10.1001/jamaoncol.2022.5425.CrossRefPubMed

Title: Exploring the Relationship: Low-Grade Appendiceal Mucinous Neoplasms (LAMN) and Mucinous Adenocarcinoma as Phases of the Same Disease Spectrum
Authors: Lance D. Miller, PhD
Konstantinos I. Votanopoulos, MD, PhD
Publication date: 28-08-2023
Publisher: Springer International Publishing
Published in: Annals of Surgical Oncology / Issue 12/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-023-14076-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Exploring the Relationship: Low-Grade Appendiceal Mucinous Neoplasms (LAMN) and Mucinous Adenocarcinoma as Phases of the Same Disease Spectrum

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

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