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27-06-2023 | Melanoma | Melanoma

The Role of Clinicopathologic Nomograms for Melanoma in the Era of Gene Expression Profiling

Authors: Raghav Tripathi, MD, MPH, Karen Larson, PhD, Graham Fowler, BA, John T. Vetto, MD, Jeremy S. Bordeaux, MD, MPH, Wesley Y. Yu, MD

Published in: Annals of Surgical Oncology | Issue 11/2023

Excerpt

Sentinel lymph node biopsy (SLNB) status is an important prognostic indicator for determining candidacy for adjuvant therapy in patients with melanoma, but is best utilized in patients with a high pretest probability of regional metastasis.¹ Our study pooled data from the National Cancer Database (NCDB; 2004–2015) and the Surveillance, Epidemiology, and End Results [SEER] database (2000–2017) to develop and internally validate a nomogram to predict SLNB positivity in melanoma.² This nomogram was externally validated using data from a large tertiary referral center, and the model was found to be comparable in accuracy to other published clinicopathologic nomograms.^3‐5 …

Wong SL, Faries MB, Kennedy EB, et al. Sentinel lymph node biopsy and management of regional lymph nodes in melanoma: american society of clinical oncology and society of surgical oncology clinical practice guideline update. Ann Surg Oncol. 2018;25(2):356–77. https://doi.org/10.1245/s10434-017-6267-7.CrossRefPubMed

Tripathi R, Larson K, Fowler G, et al. A clinical decision tool to calculate pretest probability of sentinel lymph node metastasis in primary cutaneous melanoma. Ann Surg Oncol. 2023;30(7):4321–8. https://doi.org/10.1245/S10434-023-13220-0.CrossRefPubMedPubMedCentral

Maurichi A, Miceli R, Eriksson H, et al. Factors affecting sentinel node metastasis in thin (T1) cutaneous melanomas: development and external validation of a predictive nomogram. J Clin Oncol. 2020;38(14):1591–601. https://doi.org/10.1200/JCO.19.01902.CrossRefPubMedPubMedCentral

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Tripathi R, Mazmudar RS, Knusel KD, Bordeaux JS, Scott JF. Big data in dermatology: Publicly available health care databases for population health research. J Am Acad Dermatol. 2020;83(5):1546–56. https://doi.org/10.1016/j.jaad.2020.04.145.CrossRefPubMed

Title: The Role of Clinicopathologic Nomograms for Melanoma in the Era of Gene Expression Profiling
Authors: Raghav Tripathi, MD, MPH
Karen Larson, PhD
Graham Fowler, BA
John T. Vetto, MD
Jeremy S. Bordeaux, MD, MPH
Wesley Y. Yu, MD
Publication date: 27-06-2023
Publisher: Springer International Publishing
Keywords: Melanoma
Melanoma
Published in: Annals of Surgical Oncology / Issue 11/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-023-13814-8

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The Role of Clinicopathologic Nomograms for Melanoma in the Era of Gene Expression Profiling

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