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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2013

01-12-2013 | Bone and Soft Tissue Sarcomas

Prognosis of Solitary Fibrous Tumors: A Multicenter Study

Authors: Winan J. van Houdt, MD, PhD, Charlotte M. A. Westerveld, MD, Joyce E. P. Vrijenhoek, MD, Joost van Gorp, MD, PhD, Frits van Coevorden, MD, PhD, Cornelis Verhoef, MD, PhD, Thijs van Dalen, MD, PhD

Published in: Annals of Surgical Oncology | Issue 13/2013

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Abstract

Background

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors, and data regarding outcome and prognostic factors are scarce. We report the outcome and analysis of prognostic factors of a retrospective multicenter cohort study for patients treated for SFTs.

Methods

Retrospective analysis was performed of patients treated for SFTs between 1995 and 2012. Clinical and histopathological features were analyzed for prognostic value. Endpoints were set at local recurrence, metastasis formation, or death. Survival was analyzed using Kaplan–Meier and Cox proportional hazards analyses.

Results

A total of 81 patients underwent surgical resection of a SFT with curative intent. During follow-up, 21 patients developed distant metastases, while 18 patients developed local recurrence. The 5-year overall survival was 84 %. The local recurrence rate and the metastasis rate at 5 years were 29 and 34 %, respectively. Of all factors analyzed, positive resection margin significantly correlated with local recurrence [hazard ratio (HR) 4.8; 95 % confidence interval (95 % CI) 1.5–14.9]. Tumor size >10 cm (HR 4.4; 95 % CI 1.7–11.5) and high mitosis rate (HR 3.3; 95 % CI 1.06–10.3) significantly correlated with higher incidence of metastases. The combination of tumors >10 cm and high mitosis rate significantly correlated with higher incidence of metastases (HR 4.8; 95 % CI 1.4–16.2) and showed a trend toward worse overall survival (HR 5.7; 95 % CI 0.95–34.7).

Conclusions

A substantial portion of patients with a SFT developed local recurrence or metastases. Local recurrence is significantly higher in patients with positive resection margins; metastasis frequency is significantly higher in patients with tumors >10 cm and tumors with a high mitosis rate.
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Metadata
Title
Prognosis of Solitary Fibrous Tumors: A Multicenter Study
Authors
Winan J. van Houdt, MD, PhD
Charlotte M. A. Westerveld, MD
Joyce E. P. Vrijenhoek, MD
Joost van Gorp, MD, PhD
Frits van Coevorden, MD, PhD
Cornelis Verhoef, MD, PhD
Thijs van Dalen, MD, PhD
Publication date
01-12-2013
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 13/2013
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-013-3242-9

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