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01-06-2013 | Thoracic Oncology

Repeated Resection of Colorectal Cancer Pulmonary Oligometastases: Pooled Analysis and Prognostic Assessment

Authors: Samer Salah, MD, Kazuhiro Watanabe, MD, PhD, Joon Suk Park, MD, Alaa Addasi, MD, Ji Won Park, MD, Jon Zabaleta, MD, Francesco Ardissone, MD, Jhingook Kim, MD, PhD, Marc Riquet, MD, PhD, Kazunori Nojiri, MD, PhD, Mara Gisabella, MD, Sun Young Kim, MD, Kuniya Tanaka, MD, PhD

Published in: Annals of Surgical Oncology | Issue 6/2013

Abstract

Background

Repeated resection of colorectal cancer pulmonary metastasis is associated with long-term survival. Nevertheless, very limited data addressing the best candidates for repeated pulmonary resection is available.

Patients and Methods

We searched the PubMed database for retrospective studies evaluating lung metastasectomy for metastatic colorectal cancer (CRC). We included studies with available data about repeated pulmonary metastasectomy. Potential prognostic factors were analyzed for possible impact on survival following the second metastasectomy through univariate and multivariate analysis.

Results

Between 1983 and 2008, 944 lung metastasectomies were carried out on 759 patients. Of those, 148 patients had a second metastasectomy. The 5-year survival rate was 52 % for patients who had 1 metastasectomy and 57.9 % from the second metastasectomy for patients who had repeated resection. More than 2 metastatic pulmonary nodules and maximum diameter of largest pulmonary nodule ≥3 cm were the only independent factors associated with inferior survival following repeated pulmonary resection.

Conclusions

In selected patients with metastatic CRC, repeated pulmonary metastasectomy offers an excellent chance for long-term survival and is associated with a quite low operative mortality. Patients with more than 2 metastatic nodules and a maximum diameter of the largest metastatic lung nodule of ≥3 cm have a significantly inferior survival.

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Title: Repeated Resection of Colorectal Cancer Pulmonary Oligometastases: Pooled Analysis and Prognostic Assessment
Authors: Samer Salah, MD
Kazuhiro Watanabe, MD, PhD
Joon Suk Park, MD
Alaa Addasi, MD
Ji Won Park, MD
Jon Zabaleta, MD
Francesco Ardissone, MD
Jhingook Kim, MD, PhD
Marc Riquet, MD, PhD
Kazunori Nojiri, MD, PhD
Mara Gisabella, MD
Sun Young Kim, MD
Kuniya Tanaka, MD, PhD
Publication date: 01-06-2013
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 6/2013
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-012-2860-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Repeated Resection of Colorectal Cancer Pulmonary Oligometastases: Pooled Analysis and Prognostic Assessment

Abstract

Background

Patients and Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Patients and Methods

Results

Conclusions

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