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01-03-2013 | Head and Neck Oncology

Sonographic Characteristics Suggesting Papillary Thyroid Carcinoma According to Nodule Size

Authors: Ga Ram Kim, MD, Myung Hyun Kim, MD, Hee Jung Moon, MD, PhD, Woong Youn Chung, MD, PhD, Jin Young Kwak, MD, PhD, Eun-Kyung Kim, MD, PhD

Published in: Annals of Surgical Oncology | Issue 3/2013

Abstract

Purpose

To determine differences in ultrasonography (US) features suggesting papillary thyroid carcinoma (PTC) between nodules larger than 10 mm (large lesions) and nodules ≤10 mm in diameter (small lesions).

Methods

We included 1,238 nodules in 1,173 patients that were confirmed through cytology or histopathology between February 2007 and June 2007 in the study. Nodules were divided into large lesions (571 lesions) and small lesions (667 lesions). Sonographic features were defined as composition, echogenicity, margin, calcifications, shape, and vascularity. Logistic regression analyses were performed to determine the odds ratios (OR) of each feature to predict PTC.

Results

On multivariate analysis, irregular margin (OR = 37.788, P < 0.001), microcalcifications (OR = 17.799, P < 0.001), microlobulated margin (OR = 10.385, P < 0.001), and no vascularity (OR = 5.975, P < 0.001) were independent factors for PTC in the large lesions and irregular margin (OR = 7.185, P < 0.001), microlobulated margin (OR = 5.952, P < 0.001), microcalcifications (OR = 3.722, P < 0.001), marked hypoechogenicity (OR = 2.873, P = 0.004), and taller than wide shape (OR = 2.698, P < 0.001) were independent factors for PTC in the small lesions.

Conclusions

The OR of each US finding for predicting PTC is different between large and small lesions. Therefore, it would be helpful to weight certain US features according to nodule size when reporting thyroid nodules with different risks of PTC.

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Title: Sonographic Characteristics Suggesting Papillary Thyroid Carcinoma According to Nodule Size
Authors: Ga Ram Kim, MD
Myung Hyun Kim, MD
Hee Jung Moon, MD, PhD
Woong Youn Chung, MD, PhD
Jin Young Kwak, MD, PhD
Eun-Kyung Kim, MD, PhD
Publication date: 01-03-2013
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 3/2013
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-012-2830-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sonographic Characteristics Suggesting Papillary Thyroid Carcinoma According to Nodule Size

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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