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01-07-2011 | Translational Research and Biomarkers

Polymorphism in Epidermal Growth Factor Receptor Intron 1 Predicts Prognosis of Patients with Esophageal Cancer after Chemoradiation and Surgery

Authors: Jang-Ming Lee, MD, PhD, Shi-Yi Yang, BS, Pei-Wen Yang, PhD, Chia-Tung Shun, MD, Ming-Tsang Wu, MD, ScD, Chih-Hung Hsu, MD, PhD, Chia-Chi Lin, MD, PhD, Jason Chia-Hsien Cheng, MD, PhD, Ying-Hao Wang, MS, Tzu-Hsuen Chuang, MS, Jin-Shing Chen, MD, PhD, Hsao-Hsun Hsu, MD, Pei-Ming Huang, MD, Shuenn-Wen Kuo, MD, Yung-Chie Lee, MD, PhD

Published in: Annals of Surgical Oncology | Issue 7/2011

Abstract

Background

The EGFR gene has been demonstrated to be an important factor influencing treatment response for various cancers, and its expression has been shown to be modified by the polymorphic CA repeat length at the 5′-regulatory sequence in intron 1. We investigated whether this EGFR polymorphism is associated with prognosis in patients with esophageal cancer after concurrent chemoradiotherapy (CCRT) and esophagectomy.

Methods

A cohort of 148 patients with esophageal cancer received cisplatin-based CCRT (concurrently combined with 40 Gy irradiation) and subsequent esophagectomy. Their EGFR genotypes were determined by polymerase chain reaction from leukocyte DNA, which was obtained before treatment and was correlated with patient survival.

Results

Patients with the homozygous short allele (<20 CA) of the EGFR gene in intron 1 were more likely to have a shorter duration of survival after CCRT and surgery than those with the homozygous long allele [adjusted hazard ratio (HR) (95% confidence interval [CI]) of death: 1.88 (1.02–3.49); P = 0.045]. This unfavorable prognostic effect of EGFR homozygous short CA repeat was mainly manifested in patients with good response to CCRT [adjusted HR (95% CI) of death 3.40 (1.06–10.89); P = 0.039]; it was less evident in those with poor response to CCRT [adjusted HR (95% CI) 1.40 (0.65–3.02); P = 0.384].

Conclusions

The EGFR CA repeat genetic polymorphism may act as a valuable molecular predictor of clinical outcome of esophageal cancer after CCRT and esophagectomy, especially in those with good response to CCRT.

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Title: Polymorphism in Epidermal Growth Factor Receptor Intron 1 Predicts Prognosis of Patients with Esophageal Cancer after Chemoradiation and Surgery
Authors: Jang-Ming Lee, MD, PhD
Shi-Yi Yang, BS
Pei-Wen Yang, PhD
Chia-Tung Shun, MD
Ming-Tsang Wu, MD, ScD
Chih-Hung Hsu, MD, PhD
Chia-Chi Lin, MD, PhD
Jason Chia-Hsien Cheng, MD, PhD
Ying-Hao Wang, MS
Tzu-Hsuen Chuang, MS
Jin-Shing Chen, MD, PhD
Hsao-Hsun Hsu, MD
Pei-Ming Huang, MD
Shuenn-Wen Kuo, MD
Yung-Chie Lee, MD, PhD
Publication date: 01-07-2011
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 7/2011
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-011-1559-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Polymorphism in Epidermal Growth Factor Receptor Intron 1 Predicts Prognosis of Patients with Esophageal Cancer after Chemoradiation and Surgery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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